Iu A Aleksandrovskiĭ

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An experimental and clinico-pharmacological study of sodium valproate, a GABA-ergic drug, was conducted to elucidate the role of gamma-aminobutyric acid in the mechanisms responsible for affective disturbances, in particular for anxiety. A tranquilizing effect of the drug, comparable with the action of diazepam, was established in a conflict situation model(More)
Lipid peroxidation in biological membranes was studied in healthy individuals under emotional stress and in patients with neurosis. The plasma levels of malonic dialdehyde (one of the end products of peroxidation) directly correlated with the severity of emotional stress. Patients with neurotic disturbances showed activation of peroxidation expressed in(More)
We examined 143 patients, aged 18-65 years, with chronic low back pain, in 78 of patients diagnosed as chronic somatoform pain disorder (CSPD)--ICD-10 F45.4--and in 65 as chronic pain syndrome (CPS) caused by spine pathology (M48.0, M51.1, M54.4). Depressive symptoms predominated in CSPD patients, who exhibited more pronounced psychopathological(More)
Analysis is made of mental disorders seen in 3431 victims followed up by psychiatrists in 11 large-scale catastrophies and natural disasters. Three periods of the development of the life-threatening situation were distinguished, during which one can see different states of mental disadaptation and morbid disorders. The clinical picture of such disorders is(More)
Discussed are problems of the methodology of diagnosing neuroses, neurosis-like and other borderline mental disorders. The necessity is emphasized of complex and systemic analysis of general somatic, psychological and psychopathological states. An important place is taken by dynamic analysis of the development of pathological states. The importance of these(More)
The results of the multicenter study of zolpidem activity, being carried out in inpatient- and out-patient clinics of 20 cities in Russia, are reported. One thousand seventeen patients with transitory, short time and chronic dyssomnia have been included in the trial. Zolpidem (ivadal, "Sanofi-Syntelabo", France) has been prescribed once a day in a dose of(More)
A comprehensive comparative approach was used to assess the effectiveness of the psychophysiological indices as predictors of the effect of tranquilizing therapy with benzodiazepine drugs in neurotic patients. The study resulted in selection of several psychophysiological characteristics most relevant to the prognosis of individual responses to the(More)