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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Cells, the basic units of biological structure and function, vary broadly in type and state. Single-cell genomics can characterize cell identity and function, but limitations of ease and scale have… Expand
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Cancer at single-cell resolution Single-cell sequencing can illuminate the genetic properties of brain cancers and reveal heterogeneity within a tumor. Patel et al. examined the genome sequence of… Expand
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Single-cell expression profiles of melanoma Tumors harbor multiple cell types that are thought to play a role in the development of resistance to drug treatments. Tirosh et al. used single-cell… Expand
A genetic signature of interspecies variations in gene expression
Phenotypic diversity is generated through changes in gene structure or gene regulation. The availability of full genomic sequences allows for the analysis of gene sequence evolution. In contrast,… Expand
Two strategies for gene regulation by promoter nucleosomes.
Chromatin structure is central for the regulation of gene expression, but its genome-wide organization is only beginning to be understood. Here, we examine the connection between patterns of… Expand
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.
Histone monoubiquitylation is implicated in critical regulatory processes. We explored the roles of histone H2B ubiquitylation in human cells by reducing the expression of hBRE1/RNF20, the major… Expand
A Yeast Hybrid Provides Insight into the Evolution of Gene Expression Regulation
Gene Expression in Hybrids A large proportion of genes differ in their expression patterns between closely related species, and this divergence is believed to be an important driver of phenotypic… Expand
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend… Expand
A single-cell survey of the small intestinal epithelium
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial cells from… Expand
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
- S. Puram, Itay Tirosh, Anuraag S Parikh, Anoop P. Patel, B. Bernstein
- Medicine, Biology
- 1 November 2017
The diverse malignant, stromal, and immune cells in tumors affect growth, metastasis, and response to therapy. We profiled transcriptomes of ∼6,000 single cells from 18 head and neck squamous cell… Expand