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In recent years, the introduction of massively parallel sequencing platforms for Next Generation Sequencing (NGS) protocols, able to simultaneously sequence hundred thousand DNA fragments, dramatically changed the landscape of the genetics studies. RNA-Seq for transcriptome studies, Chip-Seq for DNA-proteins interaction, CNV-Seq for large genome nucleotide(More)
Two dimensional reduction regression methods to predict a scalar response from a discretized sample path of a continuous time covariate process are presented. The methods take into account the functional nature of the predictor and are both based on appropriate wavelet decompositions. Using such decompositions, we derive prediction methods that are similar(More)
The main goal of the whole transcriptome analysis is to correctly identify all expressed transcripts within a specific cell/tissue - at a particular stage and condition - to determine their structures and to measure their abundances. RNA-seq data promise to allow identification and quantification of transcriptome at unprecedented level of resolution,(More)
A major goal of bioinformatics is the characterization of transcription factors and the transcriptional programs they regulate. Given the speed of genome sequencing, we would like to quickly annotate regulatory sequences in newly-sequenced genomes. In such cases, it would be helpful to predict sequence motifs by using experimental data from closely related(More)
—Radiances observed by the Interferometric Monitor for Greenhouse gases sounder have been used to retrieve temperature , water vapor, and ozone profiles. It is shown that the sounder allows us to simultaneously retrieve stable solutions for temperature and water vapor. Once water vapor and temperature have been retrieved, ozone profile may be estimated on(More)
International initiatives such as the Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) are collecting multiple datasets at different genome-scales with the aim of identifying novel cancer biomarkers and predicting survival of patients. To analyze such data, several statistical methods have been applied, among them Cox(More)