Istvan Samu

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A 5-year follow-up investigation of TD was carried out in 85 Hungarian schizophrenic out-patients. No substantial changes occurred during the 5 years in pharmacotherapy: most patients continued on neuroleptics and antiparkinson drugs. Comparison of 1978 and 1983 ratings revealed increased dyskinesia scores, which was statistically significant on the DRS(More)
One hundred and twenty-two patients comprising 82% of the non-hospitalized schizophrenic population of a Hungarian town were rated for tardive dyskinesia (TD). Drug histories were also obtained. No severe cases of TD were found. The markedly lower prevalence of TD in the study population in contrast to similar North American samples may be related to(More)
Of 122 Hungarian outpatients treated with neuroleptics, 79 (64.8%) were available for follow-up 7 years after their original assessment for tardive dyskinesia (TD). Ratings on the Abnormal Involuntary Movements Scale and the Simpson Dyskinesia Rating Scale increased significantly. The number of TD cases identified by research diagnostic criteria increased(More)
Propranolol induces basal achlorhydria in 30.7% of the patients, decreases significantly the HCl secretion in 42.3%, does not change it in 25% and increases it in 1.9%. After histamine stimulation (Kay test) propranolol decreases HCl in 57% and increases it in 43% of the cases. Propranolol induces a significant decrease of carbon anhydrase in the gastric(More)
An antiparkinson drug (APK) withdrawal study was carried out in 34 schizophrenic outpatients on maintenance neuroleptics. Sixty-five percent of patients were without major complaints after 2 weeks of APK discontinuation, while 35% reported adverse effects including extrapyramidal, autonomic, and behavioral symptoms. Male patients and those on higher(More)
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