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Journals and Conferences
New C-20' alkyl congeners of vinblastine (VBL) were examined for their reaction with purified microtubule protein or steady-state microtubules in vitro. We found that each of the three typical activities of VBL with this system was amenable to alteration through structural modification of the molecule at this single site. The activity profiles were… (More)
One mechanism used by plants to respond to infection is the production of antimicrobial peptides (AMPs). In addition to a role in defence, AMPs seem to have other biological functions. Furthermore, the number of cysteine-rich AMP-like peptides appears to have been underpredicted in plant genomes. Such peptides could be involved in plant defence and/or in… (More)
By combining substituted anilines with functionalized orthoesters, an efficient and connective methodology for the preparation of benzoxazole, benzothiazole, and benzimidazole derivatives has been established. The versatility of this approach enables the development of new libraries of heterocycles containing multifunctional sites.
Plants modify their volatile chemical signature under pest infestation, which might directly or indirectly improve their defence against threats. These chemical signals have potential in integrated pest management strategies. Macrolophus pygmaeus (Rambur) [Heteroptera: Miridae] is a generalist predatory insect widely used to control the tomato leaf miner,… (More)
The electrolysis of toluate esters leads smoothly to the formation of the radical of the alkyl fragment. This property has been used to develop a new electrochemical deoxygenation reaction.
Alcohols can be easily and chemoselectively deprotected from the corresponding aromatic esters by using either SmI(2)/HMPA or by electrolysis in the presence of a proton source.
The electrochemical reduction of diphenylphosphinate esters leads smoothly and in high yields to the corresponding deoxygenated products. In comparison with the previously developed methodologies, the electrolysis could be performed at lower temperature and with a higher current density, resulting in a shorter reaction time.
The first condensations between bis(trimethylsilyloxy)cyclobutene derivatives and functionalized orthoesters are reported. The resulting adducts are readily converted into spirocycloethers, which undergo a variety of -CH2- and -O- insertions with excellent regioselectivity.