István Szentistványi

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The ionic regulating of lithium homeostasis and steady-state intra:extracellular lithium distribution in the brain can be approached by experimental methods using intact nerve cells in vitro. Primary cultures prepared from chick embryonic brain were applied to study the effect of extracellular sodium and potassium on the lithium uptake of nerve cells at(More)
The red blood cell/plasma concentration ratio (LR) was studied in 45 female patients with bipolar affective illness who responded to prophylactic lithium treatment. Patients were subdivided according to bipolar I vs. bipolar II diagnosis and presence vs. absence of a family history of affective illness. Mean LRs were significantly higher in bipolar II(More)
Lithium chloride was added in 5 and 10 mM concentrations for different periods of exposition time to dissociated cultures obtained from chicken embryonic brain. When supplementing lithium at day 1 in vitro for five days, a dose-dependent decrease in total protein was observed in the cultures as compared to the sodium-treated controls. Profound reduction was(More)
The aim of the study was to determine any alteration of the 24 h motor activity pattern of a bipolar patient in different mood states. Actigraphic records were collected on an outpatient basis for a total of 387 days. The daily actograms were synchronized in phase to the time of morning awakening before averaging, which significantly enhanced the structure(More)
An account is given of the therapeutic experience with lithium in childhood hyperaggressivity. In 13 cases of the hospitalized 17 children between 3 and 12 years of age significant rehabilitation was achieved. Their sociability and ability to adapt themselves to the environment improved to a tolerable level. During treatment, no irreversible side effects(More)
The red blood cell/plasma lithium ratio (LR) has been studied in 14 schizophrenic (paranoid type), 22 schizoaffective, and 86 manic-depressive patients. Mean LR proved to be significantly higher in manic-depressive patients (p less than 0.001) as compared to the other two groups which on the other hand did not differ significantly from each other. There was(More)
Preferential swelling and vacuolation of dendrites were observed electron microscopically in different brain regions of rats treated with LiCl in a dose of 6-18 mmol/kg for 1-6 days. The most severe fine structural changes were revealed in the hippocampus. Low-dose (0.33 mmol/kg) lithium treatment lasting for a year did not cause any morphologically(More)
The steady state red blood cell/plasma lithium (Li) ratios were determined simultaneously with the in vitro rates of sodium-dependent Li transport of erythrocytes during prophylactic Li therapy in 30 unipolar, 52 bipolar forms of manic-depressive patients and in 58 nonmanic-depressive psychiatric patients as a control group. A reciprocal correlation was(More)