István Juhász

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Trastuzumab is a recombinant antibody drug that is widely used for the treatment of breast cancer. Despite encouraging clinical results, some cancers are primarily resistant to trastuzumab, and a majority of those initially responding become resistant during prolonged treatment. The mechanisms of trastuzumab resistance have not been fully understood. We(More)
Let P be a property (or, equivalently, a class) of topological spaces. A space X is called P-bounded if every subspace of X with (or in) P has compact closure. Thus, countable-bounded has been known as ω-bounded and (σ-compact)-bounded as strongly ω-bounded. In this paper we present a systematic study of the interrelations of these two known " boundedness "(More)
For any space X, denote by dis(X) the smallest (infinite) cardinal κ such that κ many discrete subspaces are needed to cover X. It is easy to see that if X is any crowded (i.e. dense-in-itself) compactum then dis(X) m, where m denotes the additivity of the meager ideal on the reals. It is a natural, and apparently quite difficult, question whether in this(More)
P-glycoprotein (Pgp) is one of the active efflux pumps that are able to extrude a large variety of chemotherapeutic drugs from the cells, causing multidrug resistance. The conformation-sensitive UIC2 monoclonal antibody potentially inhibits Pgp-mediated substrate transport. However, this inhibition is usually partial, and its extent is variable because UIC2(More)
We introduce a new reflection principle which we call " Fodor-type Reflection Principle " (FRP). This principle follows from but is strictly weaker than Fleissner's Axiom R. For instance, FRP does not impose any restriction on the size of the continuum, while Axiom R implies that the continuum has size ≤ ℵ 2. We show that FRP implies that every locally(More)
We give restrictions on the cardinality of compact Hausdorff homogeneous spaces that do not use other cardinal invariants, but rather covering and separation properties. In particular, we show that it is consistent that every hereditarily normal homogeneous compactum is of cardinality c. We introduce property wD(κ), intermediate between the properties of(More)
Expression of multidrug pumps including P-glycoprotein (MDR1, ABCB1) in the plasma membrane of tumor cells often results in decreased intracellular accumulation of anticancer drugs causing serious impediment to successful chemotherapy. It has been shown earlier that combined treatment with UIC2 anti-Pgp monoclonal antibody (mAb) and cyclosporine A (CSA) is(More)
We consider the question of whether a compact space will always have a discrete subset whose closure has the same cardinality as the whole space. We obtain many positive results for compact spaces of countable tight-ness and a consistent negative result for a space of tightness and density ω 1. Several authors have recently been investigating a notion(More)
Let us call a function f from a space X into a space Y preserving if the image of every compact subspace of X is compact in Y and the image of every connected subspace of X is connected in Y. By elementary theorems a continuous function is always preserving. Evelyn R. McMillan [6] proved in 1970 that if X is Hausdorff, locally connected and Frèchet, Y is(More)