Learn More
For any space X, denote by dis(X) the smallest (infinite) cardinal κ such that κ many discrete subspaces are needed to cover X. It is easy to see that if X is any crowded (i.e. dense-in-itself) compactum then dis(X) m, where m denotes the additivity of the meager ideal on the reals. It is a natural, and apparently quite difficult, question whether in this(More)
We introduce a new reflection principle which we call " Fodor-type Reflection Principle " (FRP). This principle follows from but is strictly weaker than Fleissner's Axiom R. For instance, FRP does not impose any restriction on the size of the continuum, while Axiom R implies that the continuum has size ≤ ℵ 2. We show that FRP implies that every locally(More)
We give restrictions on the cardinality of compact Hausdorff homogeneous spaces that do not use other cardinal invariants, but rather covering and separation properties. In particular, we show that it is consistent that every hereditarily normal homogeneous compactum is of cardinality c. We introduce property wD(κ), intermediate between the properties of(More)
Expression of multidrug pumps including P-glycoprotein (MDR1, ABCB1) in the plasma membrane of tumor cells often results in decreased intracellular accumulation of anticancer drugs causing serious impediment to successful chemotherapy. It has been shown earlier that combined treatment with UIC2 anti-Pgp monoclonal antibody (mAb) and cyclosporine A (CSA) is(More)
In software industry model transformations are used in a more and more extensive manner. Model Transformation is about transforming a high level model into a different or more detailed representation. These transformations form the backbone of the Model Driven Software Engineering approach in which the development process is about to transform a high level(More)
We investigate the question which (separable metrizable) spaces have a 'large' almost disjoint family of connected (and locally connected) sets. Every compact space of dimension at least 2 as well as all compact spaces containing an 'uncountable star' have such a family. Our results show that the situation for 1-dimensional compacta is unclear.
Extending a result of R. de la Vega, we prove that an infinite homogeneous compactum has cardinality c if either it is the union of countably many dense or finitely many arbitrary count-ably tight subspaces. The question if every infinite homogeneous and σ-countably tight compactum has cardinality c remains open. We also show that if an arbitrary product is(More)
In this paper, we investigated the isoform-specific roles of certain protein kinase C (PKC) isoforms in the regulation of skeletal muscle growth. Here, we provide the first intriguing functional evidence that nPKCδ (originally described as an inhibitor of proliferation in various cells types) is a key player in promoting both in vitro and in vivo skeletal(More)