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Let P be a property (or, equivalently, a class) of topological spaces. A space X is called P-bounded if every subspace of X with (or in) P has compact closure. Thus, countable-bounded has been known as ω-bounded and (σ-compact)-bounded as strongly ω-bounded. In this paper we present a systematic study of the interrelations of these two known " boundedness "(More)
For any space X, denote by dis(X) the smallest (infinite) cardinal κ such that κ many discrete subspaces are needed to cover X. It is easy to see that if X is any crowded (i.e. dense-in-itself) compactum then dis(X) m, where m denotes the additivity of the meager ideal on the reals. It is a natural, and apparently quite difficult, question whether in this(More)
We introduce a new reflection principle which we call " Fodor-type Reflection Principle " (FRP). This principle follows from but is strictly weaker than Fleissner's Axiom R. For instance, FRP does not impose any restriction on the size of the continuum, while Axiom R implies that the continuum has size ≤ ℵ 2. We show that FRP implies that every locally(More)
We give restrictions on the cardinality of compact Hausdorff homogeneous spaces that do not use other cardinal invariants, but rather covering and separation properties. In particular, we show that it is consistent that every hereditarily normal homogeneous compactum is of cardinality c. We introduce property wD(κ), intermediate between the properties of(More)
Expression of multidrug pumps including P-glycoprotein (MDR1, ABCB1) in the plasma membrane of tumor cells often results in decreased intracellular accumulation of anticancer drugs causing serious impediment to successful chemotherapy. It has been shown earlier that combined treatment with UIC2 anti-Pgp monoclonal antibody (mAb) and cyclosporine A (CSA) is(More)
We consider the question of whether a compact space will always have a discrete subset whose closure has the same cardinality as the whole space. We obtain many positive results for compact spaces of countable tight-ness and a consistent negative result for a space of tightness and density ω 1. Several authors have recently been investigating a notion(More)
Let us call a function f from a space X into a space Y preserving if the image of every compact subspace of X is compact in Y and the image of every connected subspace of X is connected in Y. By elementary theorems a continuous function is always preserving. Evelyn R. McMillan [6] proved in 1970 that if X is Hausdorff, locally connected and Frèchet, Y is(More)
In this paper we use a natural forcing to construct a left-separated topology on an arbitrary cardinal κ. The resulting left-separated space X κ is also 0-dimensional T 2 , hereditarily Lindelöf, and countably tight. Moreover if κ is regular then d(X κ) = κ, hence κ is not a caliber of X κ , while all other uncountable regular cardinals are. This implies(More)
In this paper, we investigated the isoform-specific roles of certain protein kinase C (PKC) isoforms in the regulation of skeletal muscle growth. Here, we provide the first intriguing functional evidence that nPKCδ (originally described as an inhibitor of proliferation in various cells types) is a key player in promoting both in vitro and in vivo skeletal(More)