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We consider a globally hyperbolic, stationary spacetime containing a black hole but no white hole. We assume, further, that the event horizon, N , of the black hole is a Killing horizon with compact cross-sections. We prove that if surface gravity is non-zero constant throughout the horizon one can globally extend such a spacetime so that the image of N is(More)
We consider smooth electrovac spacetimes which represent either (A) an asymptotically flat, stationary black hole or (B) a cosmological spacetime with a compact Cauchy horizon ruled by closed null geodesics. The black hole event horizon or, respectively, the compact Cauchy horizon of these spacetimes is assumed to be a smooth null hypersurface which is(More)
BACKGROUND Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention. METHODS The Prevention of Colorectal Sporadic Adenomatous Polyps trial was a randomized, placebo-controlled, double-blind study of the COX-2 inhibitor(More)
BACKGROUND Suppressing acid secretion is thought o reduce the risk of ulcers associated with regular use of nonsteroidal antiinflammatory drugs (NSAIDs), but the best means of accomplishing this is uncertain. METHODS We studied 541 patients who required continuous treatment with NSAIDs and who had ulcers or more than 10 erosions in either the stomach or(More)
Propofol sedation by non-anesthesiologists is an upcoming sedation regimen in several countries throughout Europe. Numerous studies have shown the efficacy and safety of this sedation regimen in gastrointestinal endoscopy. Nevertheless, this issue remains highly controversial. The aim of this evidence- and consensus-based set of guideline is to provide(More)
This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It addresses the diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH). Main Recommendations MR1. ESGE recommends immediate assessment of hemodynamic status in patients who present with acute upper gastrointestinal hemorrhage(More)
OBJECTIVES Low-dose aspirin is standard treatment for prevention of cardiovascular events in at-risk patients. However, long-term administration of low-dose aspirin is associated with a greater risk of adverse events, including gastroduodenal ulcers. This study determined the efficacy of esomeprazole for reducing the risk of gastric and/or duodenal ulcers(More)
OBJECTIVES To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN A randomised, double-blind, double-dummy, parallel group, multicentre, international, phase III non-inferiority study. (More)