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The reaction between ketenimine intermediates [generated from terminal alkynes and sulfonyl azides], diethyl azadicarboxylate, and sodium arylsulfinates in N, N-dimethylformamide at room temperature, affords ethyl 2,3-dihydro-3-oxo-4-phenyl-2-tosyl-5-(tosylamino)pyrazole-1-carboxylates in moderate-to-good yields. When diisopropyl azadicarboxylate was used(More)
The synthesis of a novel class of highly functionalized 1,3-thiazine derivatives via a copper-catalyzed tandem reaction of 1,1,3,3-tetramethylguanidine, $$\mathrm {CS}_{2}$$ CS 2 , sulfonyl azides, and terminal alkynes is described. Using isothiocyanates as the heterocumulene component, affords 2-arylimino-1,3-thiazine derivatives in moderate to good yields.
A one-pot synthesis of dihydro-1H-pyrrolizine derivatives via $$[2+3]$$ [ 2 + 3 ] cycloaddition reaction of azomethine ylides, prepared in situ from proline and ninhydrin, with dialkyl acetylenedicarboxylates, in alcohols, is described. When sarcosine was used instead of proline, functionalized spiropyrrolizines were obtained. Under these conditions, alkyl(More)
An efficient synthesis of tetraalkyl 6a-hydroxy-3-alkyl-3H,6aH-acenaphtho[1,2-g] pyrrolizine-1,2,5,6-tetracarboxylates via the 1,3-dipolar cycloaddition reaction of azomethine ylides (generated in situ from $$\alpha $$ α -amino acids and acenaphthylene-1,2-dione) with dialkyl acetylenedicarboxylates is described. When glycine was used instead of alanine,(More)
An efficient transition-metal-free approach toward C–H bond activation by using molecular $$\hbox {I}_{2}$$ I 2 -mediated $${ sp}^{3}$$ s p 3 C–H bond functionalization for the synthesis of indolizine derivatives via 1,3-dipolar cycloaddition reaction of nitrogen ylides with ynones is described.
An efficient and experimentally simple copper-catalyzed carbon–nitrogen bond formation for the synthesis of $$N$$ N -arylated biguanides starting from aryl halides, carbodiimides, and 1,1,3,3-tetramethylguanidine is reported. The potential diversity of this type of reaction, easily available starting materials, and commercially available low-cost catalysts(More)
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