Issa A Katime

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Chitosan nanoparticles crosslinked with genipin were prepared by reverse microemulsion that allowed to obtain highly monodisperse (3-20 nm by TEM) nanogels. The incorporation of genipin into chitosan was confirmed and quantitatively evaluated by UV-vis and (1)H NMR. Loosely crosslinked chitosan networks showed higher water solubility at neutral pHs than(More)
The critical micellar concentration (cmc) of the zwitterionic bile derivative CHAPS has been measured by fluorescence, light scattering and vapour pressure osmometry methods. The latter technique has been found most convenient and reliable. At 25 degrees C, in pure water, a cmc near 9 mM is found. Temperature decreases only slightly the cmc, from 9 to 7 mM(More)
Folate-chitosan conjugates were prepared by a concurrent functionalization and crosslinking reaction with the natural crosslinker genipin. Genipin molecule was employed simultaneously as crosslinker agent and spacer molecule in order to allow the functionalization with folic acid for active tumor targeting. The reaction was carried out in reverse(More)
UNLABELLED We propose here a delivery drug-polymer system using poly(N-isopropylacrylamide) (PNIPA) nanohydrogels that enables pimaricin to be protected from hostile environments and allows the controlled release of the antifungal through environmental stimuli. We synthesized 2 nanohydrogels, 1 with 100% N-isopropylacrylamide (PNIPA(5)) and 1 with 80%(More)
Solutions of the polyoxystyrene-polyoxyethylene block copolymer SO(17)EO(65), where SO denotes polystyrene oxide block as the hydrophobic block and EO the polyethylene oxide block as the hydrophilic block, in mixtures of water (a selective solvent for the EO blocks) and 1,4-dioxane (a good solvent for both blocks) were studied by surface tension and light(More)
The aim of this work was to test the application of new copolymeric poly (acrylamide-co-monomethyl itaconate) (A/MMI) hydrogels to 5-fluorouracil (5-FU) release. Three different compositions of copolymers have been studied, 90A:10MMI 75A:25MMI and 60A:40MMI. The equilibrium swelling degree in saline solution was between 76 and 80% depending on the copolymer(More)
Temperature-sensitive poly(N-isopropylacrylamide) (PNIPA) nanohydrogels were synthesized by nanoemulsion polymerization in water-in-oil systems. Several cross-linking degrees and the incorporation of acrylic acid as comonomer at different concentrations were tested to produce nanohydrogels with a wide range of properties. The physicochemical properties of(More)
Bovine-heart mitochondrial complex III was purified in the presence of Triton X-100, and the size and shape of the resulting protein-surfactant-phospholipid mixed micelles were investigated by laser light-scattering. The protein appears to be present in the form of a dimer, irrespective of temperature (between 25 and 40 degrees C) and protein concentration(More)
In this work the synthesis of smart nanoparticles capable of respond to external stimulus (pH and temperature variations) is reported. To avoid post-polymerization modification, functionalized monomers able to respond to pH and temperature changes were and then polymerized. The synthesized monomers have the capability for coupling with folic acid which is(More)
The aim of this work was to test the application of copolymeric poly(acrylamide-co-monopropyl itaconate) (A-MPI) hydrogels on the release of 5-fluorouracil (5-FU). The equilibrium degree of swelling in saline solution was 83 +/- 2%. 5-FU, as the sodium salt, was trapped in gels by placing it in the polymerization feed mixture. The diffusion coefficients for(More)