Israel Tojal

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Although patterns of somatic alterations have been reported for tumor genomes, little is known on how they compare with alterations present in non-tumor genomes. A comparison of the two would be crucial to better characterize the genetic alterations driving tumorigenesis. We sequenced the genomes of a lymphoblastoid (HCC1954BL) and a breast tumor (HCC1954)(More)
BACKGROUND Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the presence of Philadelphia chromosome (Ph) leading to expression of a BCR-ABL1 fusion oncogene. The BCR-ABL protein has a constitutive tyrosine kinase activity which is responsible for CML pathogenesis by promoting cell apoptosis resistance; however, the cellular(More)
January 31, 2017 Type Package Title Empirical Bayesian approach to mutational signature discovery Version 1.0.1 Author Rafael Rosales, Rodrigo Drummond, Renan Valieris, Israel Tojal da Silva Maintainer Renan Valieris <renan.valieris@cipe.accamargo.org.br> Description The signeR package provides an empirical Bayesian approach to mutational signature(More)
November 21, 2016 Type Package Title signeR Version 1.0.0 Author Rafael Rosales, Rodrigo Drummond, Renan Valieris, Israel Tojal da Silva Maintainer Renan Valieris <renan.valieris@cipe.accamargo.org.br> Description The signeR package provides an empirical Bayesian approach to mutational signature discovery. It is designed to analyze single nucleotide(More)
March 23, 2017 Type Package Title Empirical Bayesian approach to mutational signature discovery Version 1.0.1 Author Rafael Rosales, Rodrigo Drummond, Renan Valieris, Israel Tojal da Silva Maintainer Renan Valieris <renan.valieris@cipe.accamargo.org.br> Description The signeR package provides an empirical Bayesian approach to mutational signature discovery.(More)
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