Subcutaneous injections of adrenalin are, in contrast with its behavior in the production of the other effects of that drug, more favorable to the production of glycosuria in rabbits than intramuscular injections; the failures are fewer and the quantities of dextrose in the urine are generally larger. In general, as regards the stimulation of diuresis by… (More)
The subcutaneous injection of 1 or 2 mg. of morphine sulfate per kilo subcutaneously in dogs with a pancreatic deficiency, whose sugar tolerance is still good, produces a rise in the glycemia about four times greater than the same amount of morphine calls forth in normal dogs. As dogs with a pancreatic deficiency due to coagulation or partial resection of… (More)
In a previous communication (I) it was reported that after intravenous injections of large amounts of dextrose into normal rabbits the intestine contained on the average 1.2 per cent. of the injected dextrose, while through the kidneys about 4o per cent. of the injected dextrose was eliminated. In rabbits whose kidneys were removed previous to the injection… (More)
In a study published by one of us (1) it was stated that crystalline urease is inactivated by trypsin. Recently Waldschmidt-Leitz and Steigerwaldt (2) repeated this experiment and report that, contrary to our finding, crystalline urease is not inactivated by trypsin and therefore is not a protein as declared by Sumner and his associates and by us. This… (More)
After Blum's discovery of the production of glycosuria by the subcutaneous injection of adrenal extract, Herter has the merit of having found that injection of adrenalin into the peritoneal cavity also produces glycosuria; this is an undeniable fact. Concerning Herter's claim that intraperitoneal injection gives a higher degree of glycosuria than… (More)
1. As has been found by other investigators, when a large amount of dextrose is injected intravenously into a normal dog it disappears from the circulating blood in about 90 minutes after the end of the injection. Varying amounts (an average of 60 per cent) are excreted in the urine. 2. Even in nephrectomized animals the same quantity will leave the… (More)
1. The maltase of saliva and that of E. coli (B. coli communis) hydrolyze maltose but not alpha-methylglucoside or sucrose and are therefore to be considered glucomaltases. 2. Maltase is rapidly and completely inactivated and digested by trypsin.
The contents of the stomach and small intestine of normal rabbits, kept on a diet poor in easily convertible carbohydrates, when removed immediately after killing the animal (by clamping the trachea), usually contain a very small but measurable amount of dextrose (reducing substances). A preceding nephrectomy does not increase the amounts of the dextrose in… (More)