Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes
- Cristina Martínez-GarcíaAdriana Izquierdo-Lahuerta G. Medina-Gómez
- 6 November 2015
Biology, Environmental Science
It is concluded that lipotoxicity accelerates glomerular disease through lipid accumulation and inflammation, and saturated fatty acids specifically promote insulin resistance by disturbing the cytoarchitecture of podocytes.
Peroxisome Proliferator-Activated Receptor γ 2 Modulates Late-Pregnancy Homeostatic Metabolic Adaptations
- Yurena VivasMonica Díez-Hochleitner G. Medina-Gómez
- 19 October 2016
Medicine
Data indicate that PPARγ2 is essential in promoting healthy adipose tissue expansion and immune and metabolic functionality during pregnancy, contributing to the physiological adaptations that lead gestation to term.
Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass
- Yurena VivasCristina Martínez-García G. Medina-Gómez
- 30 December 2011
Biology, Medicine
The data suggest that the expansion of beta cell mass observed in ob/ob islets is associated with the activation of an immune response that fails to occur in POKO islets, suggesting an important role for PPARγ in maintenance/activation of mechanisms essential for the continued function of the beta cell.
Long‐term caloric restriction ameliorates deleterious effects of aging on white and brown adipose tissue plasticity
- Patricia CorralesYurena Vivas G. Medina-Gómez
- 28 March 2019
Medicine, Biology
It is shown that moderate 20% CR delays early deleterious effects of aging on white and brown adipose tissue (WAT and BAT, respectively) function and improves peripheral IR and browning in response to food restriction, as a potential therapeutic strategy to prevent the adverse metabolic effects in middle‐aged animals.
Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model
- Cristina Martínez-GarcíaA. Izquierdo G. Medina-Gómez
- 5 July 2012
Biology, Medicine
The POKO mouse is demonstrated to be a model of renal disease that is accelerated by high levels of glucose and lipid accumulation, and data suggest an accelerated lesion through glucolipotoxic effects in the renal pathogenesis in PokO mice.
Central ceramide signaling mediates obesity-induced precocious Puberty
- HerasJ. M. Castellano M. Tena-Sempere
- 15 September 2021
Medicine, Biology
Initial age-associated metabolic alterations in white and brown fat depots: effect of long-term caloric restriction.
- Patricia Corrales-CordónYurena Vivas Gema Medina
- 31 May 2019
Medicine, Biology
Resumen del poster presentado al 6th Symposium on Biomedical Research: Advances and Perspectives in Molecular Endocrinology "In Homage to Gabriella Morreale", celebrado en el Instituto de…