Islam S M Saiful

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The investigation was conducted with crude methanolic extract of leaf of Abutilon indicum for its cytotoxic and antimicrobial activity. Antimicrobial activity of the extract was evaluated against various Gram-positive, Gramnegative bacteria and fungi using disk diffusion technique. For cytotoxic activity, brine shrimp lethality bioassay was performed to(More)
Neuronal PAS protein 2 (NPAS2), a heme-binding transcriptional regulatory factor, is involved in circadian rhythms. Period homologue (Per) is another important transcriptional regulatory factor that binds to cryptochrome (Cry). The resultant Per/Cry heterodimer interacts with the NPAS2/BMAL1 heterodimer to inhibit the transcription of Per and Cry. Previous(More)
Heme-regulated eIF2alpha kinase (HRI) is an important enzyme that modulates protein synthesis during cellular emergency/stress conditions, such as heme deficiency in red cells. It is essential to identify the heme axial ligand(s) and/or binding sites to establish the heme regulation mechanism of HRI. Previous reports suggest that a His residue in the(More)
The substituent effect on the g-tensor of polycrystalline 2,6-di-tert-butyl phenoxyl radical derivatives diluted in diamagnetic crystals was investigated using multifrequency ESR spectroscopy and DFT calculations. It was revealed that the g-tensors of the series of phenoxyl radical derivatives essentially have an orthorhombic symmetry. For some radicals,(More)
EPR spectra of the excited quartet and doublet molecular states of (tetraphenylporphinato)zinc(II) covalently bounded to 3-(N-nitronyl-notroxide) pyridine stable radical are modeled in terms of the spin-Hamiltonian given by the sum of the contributions from the radical and triplet moieties, and the interaction between them. The later is represented by(More)
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