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The complex dynamics of Human Immunodeficiency Virus leads to serious problems on predicting the drug resistance. Several machine learning techniques have been proposed for modelling this classification problem, but most of them are difficult to aggregate and interpret. In fact, in last years the protein modelling of this virus has become, from diverse(More)
Particle Swarm Optimization (PSO) is a bio-inspired evolutionary meta-heuristic that simulates the social behaviour observed in groups of biological individuals [4]. In standard PSO, the particle swarm is often attracted by sub-optimal solutions when solving complex multimodal problems, causing premature convergence of the algorithm and swarm stagnation(More)
The high mutability of Human Immunodeficiency Virus (HIV) leads to serious problems on designing efficient antiviral drugs. In fact, in last years the study of drug resistance prediction for HIV mutations has become an open problem for researchers. Several machine learning techniques have been proposed for modelling this sequence classification problem, but(More)
Particle Swarm Optimization (PSO) is a nondirect search method for numerical optimization. The key advantages of this metaheuristic are principally associated to its simplicity, few parameters and high convergence rate. In the canonical PSO using a fully connected topology, a particle adjusts its position by using two attractors: the best record stored for(More)
Artificial Neural Networks (ANNs) are grouped within connectionist techniques of Artificial Intelligence. In particular, Recurrent Neural Networks are a type of ANN which is widely used in signal reproduction tasks and sequence analysis, where causal relationships in time and space take place. On the other hand, in many problems of science and engineering,(More)
Particle Swarm Optimization (PSO) is a bioinspired meta-heuristic for solving complex global optimization problems. In standard PSO, the particle swarm frequently gets attracted by suboptimal solutions, causing premature convergence of the algorithm and swarm stagnation. Once the particles have been attracted to a local optimum, they continue the search(More)
Decision-making could be defined as the process to choose a suitable decision among a set of possible alternatives in a given activity. It is a relevant subject in numerous disciplines such as engineering, psychology, risk analysis, operations research, etc. However, most real-life problems are unstructured in nature, often involving vagueness and(More)
Several antiviral drugs have been approved for treating HIV infected patients. These drugs inhibit the function of proteins which are essential in the virus life cycle, thus preventing the virus reproduction. However, due to its high mutation rate the HIV is capable to develop resistance to administered therapy. For this reason, it is important to study the(More)