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[structure: see text] A convergent total synthesis of khafrefungin was accomplished on the basis of (1) the highly stereoselective TiCl4-mediated vinylogous Mukaiyama aldol reaction using vinylketene silyl N,O-acetal and (2) syn-selective aldol reaction of enal 5a and ethyl ketone 6 followed by anti-dehydration under Mitsunobu conditions.
An efficient protocol for the generation of acylcobalt species from alkyne-[Co(2)(CO)(6)] complexes is realized by treatment of the complexes with AcOH and pyridine. The generated acylcobalt species smoothly underwent addition reactions with various alkenes to give alkyl alkenyl ketones in good yield.
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