Isao Matsumoto

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Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.

Wei Wang, Qi Li, +8 authors Seiji Yano
Clinical cancer research : an official journal of…
2009

PURPOSE Lung cancers with epidermal growth factor receptor (EGFR)-activating mutations show good clinical response to gefitinib and erlotinib, selective tyrosine kinase inhibitors (TKI) to EGFR, but… (More)

A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models.

Q S Chen, Kenzo Muramoto, +13 authors Marc S. Lamphier
British journal of pharmacology
2010

BACKGROUND AND PURPOSE Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17 cells, which infiltrate and damage tissues… (More)

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region

Aya Kawasaki, Ikue Ito, +15 authors Naoyuki Tsuchiya
Arthritis research & therapy
2008

INTRODUCTION Recent studies identified STAT4 (signal transducers and activators of transcription-4) as a susceptibility gene for systemic lupus erythematosus (SLE). STAT1 is encoded adjacently to… (More)

Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.

Keiichi Iwanami, Isao Matsumoto, +9 authors Takayuki Sumida
Arthritis and rheumatism
2008

OBJECTIVE To clarify the glucose-6-phosphate isomerase (GPI)-specific CD4+ T cell lineage involved in GPI-induced arthritis and to investigate their pathologic and regulatory roles in the induction… (More)

Invariant NKT cells produce IL-17 through IL-23-dependent and -independent pathways with potential modulation of Th17 response in collagen-induced arthritis.

Yohei Yoshiga, Daisuke Goto, +6 authors Takayuki Sumida
International journal of molecular medicine
2008

Invariant natural killer T (iNKT) cells play a protective role in the development of certain autoimmune diseases. However, their precise role in the pathogenesis of autoimmune arthritis remains… (More)

Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer.

Kenichiro Saito, Kazuyuki Kawakami, Isao Matsumoto, Makoto Oda, Go Watanabe, Toshinari Minamoto
Clinical cancer research : an official journal of…
2010

PURPOSE Global hypomethylation and the hypermethylation of gene promoter regions are common events in tumor DNA. The aim of this study was to evaluate the prognostic significance of both global… (More)

A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus.

Yoshinori Tanaka, Kazuhiko Yamamoto, +8 authors T. Koike
Modern rheumatology
2007

Although corticosteroids and immunosuppressants are widely used for the treatments of systemic lupus erythematosus (SLE), safer and more effective therapies are prerequisite. We and others have… (More)

Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

Aya Kawasaki, Satoshi Ito, +13 authors Naoyuki Tsuchiya
Arthritis research & therapy
2010

INTRODUCTION TNFAIP3 interacting protein 1, TNIP1 (ABIN-1) is involved in inhibition of nuclear factor-κB (NF-κB) activation by interacting with TNF alpha-induced protein 3, A20 (TNFAIP3), an… (More)

Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus.

Ryouta Takahashi, Akito Tsutsumi, +5 authors Takayuki Sumida
Annals of the rheumatic diseases
2005

OBJECTIVE To determine whether occurrence, characteristics, and progression of systemic lupus erythematosus (SLE) are associated with polymorphism of the mannose binding lectin (MBL) gene and with… (More)

TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

Aya Kawasaki, Hiroshi Furukawa, +9 authors Naoyuki Tsuchiya
Arthritis research & therapy
2011

INTRODUCTION The Toll-like receptor 7 (TLR7) gene, encoded on human chromosome Xp22.3, is crucial for type I interferon production. A recent multicenter study in East Asian populations, comprising… (More)

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