Isabelle Schreiber

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1. The content of glutathione and glutathione disulfide and the activity of the glutathione S-transferase were determined in the liver of pike and rat. 2. It was found that the liver of pike contains far less glutathione than the liver of rats, while the glutathione disulfide content was similar in both species. 3. The activity of the hepatic glutathione(More)
Insulin-resistance is the main cause of type 2 diabetes. Here we describe the identification and characterization of BMP2 and BMP6 as new insulin-sensitizing growth factors in mature adipocytes. We show that BMP2 and BMP6 lead to enhanced insulin-mediated glucose uptake in both insulin-sensitive and -insensitive adipocytes. We exclude a direct effect of(More)
Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP signal transduction and provide molecular insights how it integrates into the signalling pathway. We found that IRS4 interacts with the BMP(More)
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