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OBJECTIVES To describe the true incidence, prenatal detection rate and fetal outcome of congenital diaphragmatic hernia (CDH) in a systematically registered population over an 18-year period and to determine any change in trends over time. METHODS This was a retrospective study of all cases of CDH registered in the Central-Eastern France Birth Defects(More)
OBJECTIVE To investigate prevalence of iron deficiency and examine the relationship between iron status and Health-related Quality of Life among female students. DESIGN Cross-sectional study. SUBJECTS AND SETTING Data were collected from 543 female students, aged 17 to 38 years, attending University or secondary schools in Clermont-Ferrand (France) and(More)
BACKGROUND Conventional power studies possess limited ability to assess the performance of cluster detection tests. In particular, they cannot evaluate the accuracy of the cluster location, which is essential in such assessments. Furthermore, they usually estimate power for one or a few particular alternative hypotheses and thus cannot assess performance(More)
BACKGROUND Transposition of great arteries (TGA) defined as the combination of concordant atrioventricular and discordant ventriculo-arterial connections is one of the most common congenital heart defects. Prenatal diagnosis of TGA remains difficult. To determine the impact of antenatal diagnosis we evaluated the sensitivity of antenatal detection and the(More)
BACKGROUND Congenital malformations occur in 3-4% of live births. Their prenatal detection is performed by ultrasound screening. Any announcement about a suspected malformation is a source of stress for the parents, and misdiagnosis during ultrasound screening can lead to expensive and sometimes iatrogenic medical interventions. In this study, we aim to(More)
BACKGROUND The prognosis and early neonatal management of the VACTERL association depend mainly on the severity of malformations ascertained prenatally. METHODS Here we reviewed the spectrum of clinical features observed in cases of VACTERL association ascertained prenatally through ultrasound examination but examined at birth and compared them with cases(More)
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