Isabelle Durocher

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The aim of this study was to determine whether different generations (G) polyamidoamine (PAMAM) dendrimers possess proinflammatory activities in vivo. Several hundred female CD-1 mice were used to test four different PAMAM dendrimers using the murine air pouch model. Mice received appropriate negative and positive controls or G0-G3 PAMAM nanoparticles at(More)
Nowadays, silver nanoparticles (AgNP) are widely used in the medical field mainly for their antibacterial properties. Although some studies report a cytotoxic activity of the particles, the mechanisms involved in AgNP-induced cell death remain to be determined. Herein, we report that AgNP of 2 (AgNP2) and 15 nm (AgNP15) induce apoptosis in human MCF-7 and(More)
The aim of this study was to determine potential effects of gold (+) and gold (−) nanoparticles, AuNP(+) and AuNP(−), on neutrophil biology. Freshly isolated human neutrophils were used for the in vitro aspects and CD-1 mice were used in the in vivo murine air pouch model of acute neutrophilic inflammation. Human neutrophils were treated with the indicated(More)
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