Isabelle Charpentier

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After a milk meal, bucket-fed calves show non-nutritive oral activities, including cross-sucking, and this can discourage producers from rearing them in groups. Sucking is known to induce a quiet state in humans and rats. We examined if nutritive sucking affects non-nutritive oral activities in calves, if it reduces arousal (assessed through behavior and(More)
With the interactive continuation tool Diamanlab, solution branches of a parametric nonlinear problem are computed as sets of Taylor-based solutions stored in checkpoints. Theoretical aspects and implementation are generic, taking advantage of the efficient higher-order asymptotic numerical method in its Diamant form that interprets the generic nonlinear(More)
The present paper reports the preparation and characterization of two neutralizing monoclonal antibodies (Mabs), called MST1 and MST2, which bind at the central loop of a long-chain neurotoxin from cobra venom. The central loop is a critical region for the binding of the toxin to the nicotinic acetylcholine receptor. Some of the residues incorporated in the(More)
The solution structure of alpha-cobratoxin, a neurotoxin purified from the venom of the snake Naja naja siamensis, at pH 3.2 is reported. Sequence-specific assignments of the NMR resonances was attained by a combination of a generalized main-chain-directed strategy and of the sequential method. The NMR data show the presence of a triple-stranded beta-sheet(More)
Serotherapy, an approach currently used to protect humans against animal bites or stings, is often too specific. To broaden antiserum paraspecificity, use of antibodies directed against areas shared by all members of a toxin family was previously proposed. MST2 is a mAb that recognizes all long-chain curaremimetic toxins (Charpentier et al. (1990) J. Mol.(More)
Domain decomposition methods are a valuable approach when solving partial differential equation (PDE) problems on parallel computers. In this paper, we focus our attention onto parallelization strategies for these numerical methods when dealing with irregular applications, more specifically when adaptive refinement techniques [Ver96] are applied to PDE(More)