Isabelle Boucoiran

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OBJECTIVE To evaluate the screening accuracy of pregnancy hypertensive disorders by maternal serum biomarkers and uterine artery Doppler in the first trimester. STUDY DESIGN Prospectively enrolled nulliparous women had uterine artery Doppler and serum measured at 11-13 weeks. Maternal characteristics, uterine artery Doppler, and serum placental biomarkers(More)
OBJECTIVES To determine whether the parameters used in first-trimester screening for aneuploidies contribute significantly to the prediction of birth weight. METHODS In this retrospective cohort study (n = 4110), nuchal translucency (NT), free β-chorionic gonadotropin (fβ-hCG), and pregnancy-associated plasma protein-A (PAPP-A) blood concentrations were(More)
OBJECTIVES The aim of our study was to define the influence of mode of delivery in term breech presentation on the Apgar score and transfert in neonatal care unit using our university hospital protocol. MATERIAL AND METHOD We conducted a retrospective study. The study included 568 singleton term pregnancies during the period January 1996 to December 2005.(More)
OBJECTIVES (1) To describe obstetrical and neonatal outcomes among a cohort of hepatitis C virus (HCV) infected women, comparing HCV RNA positive to HCV RNA negative women; (2) to characterize virologic and hepatic parameters associated with HCV infection during pregnancy; and (3) to describe the rate of HCV vertical transmission. METHODS We prospectively(More)
BACKGROUND Anti-Müllerian hormone (AMH) levels are used to evaluate the ovarian reserve. AMH serum concentrations have recently been studied among women attending fertility centers, and among women with regular menstrual cycles but normative values have not been established among fertile women: the objective of this study was to establish those values. (More)
OBJECTIVE To analyze neonatal and maternal complications of operative vaginal delivery using spatulas. STUDY DESIGN We conducted a retrospective observational study of 1065 consecutive spatula-assisted deliveries at Nice University Hospital from 2003 through 2006, excluding stillbirths and breech deliveries. After univariate analysis, we performed(More)
OBJECTIVE To evaluate endostatin, an anti-angiogenic factor, in relation to the risk of preeclampsia (PE). STUDY DESIGN In this case control study, serum samples were collected at 11-17 weeks and 18-26 weeks' gestation. Endostatin levels were expressed as adjusted multiples of the median (MoM). Logistic regression was used to calculate adjusted odds(More)
OBJECTIVE To determine the utility of cross-trimester repeated measures of placental protein 13 (PP13), A disintegrin and metalloprotease 12 (ADAM12), and placental growth factor (PlGF) for preeclampsia (PE) screening. STUDY DESIGN A prospective cohort study of 893 nulliparous women who had serum sampling at 11 to 14 and 18 to 22 weeks. Biomarker levels(More)
OBJECTIVE To assess the stability of human immunodeficiency virus (HIV) viral load suppression within 1 month before birth in pregnant women receiving antenatal combination antiretroviral therapy (CART). METHODS This is a retrospective cohort study of a Canadian provincial perinatal HIV database from 1997 to 2015. Inclusion criteria were live birth and(More)
OBJECTIVE To determine the accuracy of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and inhibin A in singleton and multiple-gestation pregnancies for predicting preeclampsia (PE) and small for gestational age (SGA). STUDY DESIGN A prospective cohort nested in a randomized controlled trial of antioxidant supplementation for(More)