Isabelle Alvarez

Learn More
Long-distance population dispersal leaves its characteristic signature in genomes, namely, reduced diversity and increased linkage between genetic markers. This signature enables historical patterns of range expansion to be traced. Herein, we use microsatellite loci from the human pathogen Coccidioides immitis to show that genetic diversity in this fungus(More)
This paper proposes a new method to estimate the class membership probability of the cases classified by a Decision Tree. This method provides smooth class probabilities estimate, without any modification of the tree, when the data are numerical. It applies a posteriori and doesn't use additional training cases. It relies on the distance to the decision(More)
This paper proposes a new method to rank the cases classified by a decision tree. The method applies a posteriori without modification of the tree and doesn't use additional training cases. It consists in computing the distance of the cases to the decision boundary induced by the decision tree, and to rank them according to this geometric score. When the(More)
In this paper, we introduce our current research project aimed at computer-based support for participatory management of protected areas, in order to promote biodiversity conservation and social inclusion. Its applicative objective is to help various stakeholders (e.g., environmentalist NGOs, communities , tourism operators, public agencies, and so on) to(More)
This paper addresses our experience in the design of a serious game, aimed at computer-based support for intercultural participatory management of protected areas (e.g., parks, marine reserves, biosphere reserves...), in order to promote biodiversity conservation and social inclusion. Its objective is, via a computer assisted role-playing game, to help(More)
Multi-agent systems (MAS) represent an effective approach for designing and constructing collaborative applications, designed as set of autonomous entities, named agents, which interact and coordinate. Some example of references on multi-agent systems are: [1], [2] [3]. Although multi-agent systems provide an effective approach for decentralized(More)
Fexofenadine (FEX) has high solubility and low permeability (BCS, Class III). In this work, novel FEX loaded water in oil microemulsion (w/o) was designed to improve bioavailability and compared with Fexofen(®) syrup in in vitro and in vivo studies. In addition, pharmacokinetic parameters in permeability studies were estimated by using WinNonLin software(More)