Isabela Oliva

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The motor neuron (MN) degenerative disease, spinal muscular atrophy (SMA) is caused by deficiency of SMN (survival motor neuron), a ubiquitous and indispensable protein essential for biogenesis of snRNPs, key components of pre-mRNA processing. However, SMA's hallmark MN pathology, including neuromuscular junction (NMJ) disruption and sensory-motor circuitry(More)
Objectives To evaluate the clinical usefulness of lung biopsy in ventilated patients admitted to an Intensive Care Unit. Methods Retrospective descriptive study that included 16 ventilated patients admitted to the ICU, which underwent a lung biopsy between 2008 and 2013.oalveolar lavage (BAL), radiological pattern and histology, were analyzed. Changes in(More)
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