Isabela Henriques

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BACKGROUND Hypertension is the major risk factor for stroke associated with small-artery disease and large-artery disease, but the factors behind the development of a particular stroke subtype in individual patients are not known. METHODS We determined risk factors potentially predictive of stroke subtype in 822 of 2760 patients consecutively admitted to(More)
Emphysema is an intractable pulmonary disease characterized by an inflammatory process of the airways and lung parenchyma and ongoing remodeling process in an attempt to restore lung structure. There is no effective drug therapy that regenerates lung tissue or prevents the progression of emphysema; current treatment is aimed at symptomatic relief. We(More)
AIM We investigated the therapeutic effects of aerobic training on lung mechanics, inflammation, morphometry and biological markers associated with inflammation, and endothelial cell damage, as well as cardiac function in a model of elastase-induced emphysema. METHODS Eighty-four BALB/c mice were randomly allocated to receive saline (control, C) or 0.1 IU(More)
Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into(More)
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