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CONTEXT Systemic hypertension is prevalent among patients with obstructive sleep apnea (OSA). Short-term studies indicate that continuous positive airway pressure (CPAP) therapy reduces blood pressure in patients with hypertension and OSA. OBJECTIVE To determine whether CPAP therapy is associated with a lower risk of incident hypertension. DESIGN,(More)
Iron is an essential micronutrient, as it is required for adequate erythropoietic function, oxidative metabolism and cellular immune responses. Although the absorption of dietary iron (1-2 mg/d) is regulated tightly, it is just balanced with losses. Therefore, internal turnover of iron is essential to meet the requirements for erythropoiesis (20-30 mg/d).(More)
An epidemiological, dietary, toxicological and clinical nutrition study, in an area with endemic chronic arsenic poisoning, was made. In a pilot study on 100 subjects from Antofagasta Commune, water dietary intake was associated with age (r = 0.678; P less than 0.000005). In a dietary survey (N = 220), performed to measure the mean and median arsenic doses,(More)
Several major orthopaedic surgical procedures may result in significant blood loss and the need for allogeneic blood transfusion (ABT). However, overall concerns about adverse effects of ABT have prompted the review of transfusion practice and the search for transfusion alternatives to decrease or avoid the use of ABT. These strategies include the(More)
STUDY OBJECTIVE The aim of this study was to compare 2 groups of patients with severe obstructive sleep apnea (OSA) who were taking medication for cardiovascular disease: those who were compliant with nasal continuous positive airway pressure (CPAP) treatment and those who refused treatment or were noncompliant with CPAP treament. METHODS In a cohort of(More)
BACKGROUND Obstructive sleep apnea (OSA) is associated with increased risk for cardiovascular morbidity and mortality. Epidemiological and animal models studies generate hypotheses for innovative strategies in OSA management by interfering intermediates mechanisms associated with cardiovascular complications. We have thus initiated the Epigenetics(More)
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