Isabel Torgal

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To assess physical and psychological morbidity, sexual functioning and social and relationship satisfaction among women treated with pelvic radiotherapy. Observational (case–control) study of 199 women: 98 submitted to pelvic radiotherapy for the treatment of uterine, rectal or anal cancers and 101 without a personal history of cancer and similar(More)
The oocyte's primary function is to be fertilised by a spermatozoon in order to create a viable embryo. Oocyte growth and development are initiated during embryogenesis and occur in parallel to follicular development. Factors produced by the oocyte bind to receptors on follicular cells, ensuring follicular development. Oocytes begin meiosis during foetal(More)
In vivo pulmonary metastatic profile of breast cancer cell lines expressing hormonal receptors versus triple negative Breast cancer metastized to lungs is a challenge considering clinical management and molecular processes. The interaction between tumor cells and lung environment as well as the influence of hormonal receptor (HR) are a question of debate.(More)
This study concerns the evaluation of epidemiologic, clinical and laboratory parameters and the comparison of the multiple parameters between benign and malignant tumors of the ovary to establish significant criteria allowing a Malignant Risk Index to be defined. The incidence of ovarian cancer was higher among post-menopausal women with no use of oral(More)
Purpose To evaluate the anatomic and functional results of a laparoscopic modified Vecchietti technique for the creation of a neovagina in patients with congenital vaginal aplasia. Methods Retrospective study of nine patients with congenital vaginal aplasia submitted to the laparoscopic Vecchietti procedure, in our department, between 2006 and 2013. The(More)
The aim of this study was to characterize the hematogeneous spread, in vivo, of breast cancer (BC) cell lines that express hormonal receptors (HR) comparing with triple-negative (TN) BC, particularly considering the lung and liver. Female Balb/c nu nu mice (n=30) were injected with two breast cancer cell lines (MCF7 and HCC1806). Nuclear medicine imaging(More)
Breast cancer patients are stratified in 3 groups: expressing hormonal receptors (HR), which respond to therapies targeting estrogen receptors; HER2+, candidates to trastuzumab; and triple negative (TN), for which, despite its more aggressive clinical behavior, chemotherapy is therapy available. In vitro studies proved that cells subjected to specific(More)
Objective To evaluate the trends in definitive contraception in a ten-year interval comprising the years 2002 and 2012. Method Retrospective analysis of the tubal sterilization performed in our service in 2002 and 2012, analyzing the demographic characteristics, personal history, previous contraceptive method, definite contraception technique, effectiveness(More)
PURPOSE OF INVESTIGATION To characterize the risk factors for abnormal cervical cytology among women with human immunodeticiency virus (HIV), and to determine the relationship between antiretroviral therapy (ART) and cytology results. MATERIALS AND METHODS Retrospective study of clinical data of 115 HIV-infected women between January 2008 and December(More)
Endometrial cancer is the most frequent gynecological malignancy in developed world. Cancer stem cells (CSC) are recognized as a small proportion of cells among the tumor cell population that are capable of self-renewal, aberrant differentiation, and escape homeostasis. This review aims to systematize the existing evidence of CSC of endometrial cancer and(More)