Isabel M. McFarlane

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OBJECTIVES Rheumatoid arthritis (RA) has been rarely reported in association with sickle cell disease (SCD). Our study aimed to estimate the prevalence of RA in SCD population and to describe the clinical characteristics of RA associated with SCD. METHODS Retrospective chart review of SCD and RA patients followed at 2 large urban hospitals. Seven RA/SCD(More)
A simple technique for detection of serum autoantibodies that bind to liver membrane antigens on the surface of liver cells has been developed using Alexander cells[PLC/PRF/5]. Alexander cells were incubated with test serum(1:160), washed then adherent antibodies were detected by incubating with 125I-proCein A. Specific binding to cell surface was(More)
The advent of hydroxyurea and advanced medical care, including immunizations has led to improved survival among patients with Sickle Cell Disease (SCD). This prolonged survival however, introduces a chronic inflammatory disorder, Rheumatoid Arthritis (RA), which presents at a relatively older age and is rarely reported among SCD patients. In this review, we(More)
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