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BACKGROUND Most patients with dementia with Lewy bodies (DLB) exhibit diffuse plaque-only pathology with rare neocortical neurofibrillary tangles (NFTs), as opposed to the widespread cortical neurofibrillary-tau involvement in Alzheimer disease (AD). Another pathological difference is the astrocytic and microglial inflammatory responses, including release(More)
Autosomal recessive-juvenile parkinsonism (AR-JP) is one of the most common forms of familial Parkinson's disease (PD) and is related to mutations in the Park-2 gene, encoding for a protein ligase of ubiquitin, parkin. Different mutations located along the parkin gene have been observed in different AR-JP affected families, possibly interfering with the(More)
The synucleinopathies are a group of neurodegenerative disorders characterized by the presence of alpha-synuclein inclusions in neurons (Lewy body diseases, LBD) or glial cells (multiple system atrophies, MSA). Recently, nitration of alpha-synuclein has been reported as the possible modification that induces its aggregation and deposition in these(More)
Parkinson's disease (PD) is a common neurodegenerative disorder that produces progressive disability despite symptomatic treatment. Several strategies, including stereotaxic brain lesions, deep brain stimulation, transplants of dopamine cells and administration of neurotrophic factors, have been proposed to improve efficacy and to counteract the progression(More)
Steele-Richardson-Olszewski syndrome (SROS) is a neurodegenerative disorder of unknown aetiology, most frequently sporadic. Familial cases of SROS have been described. An intronic polymorphism of the tau gene is associated with sporadic SROS and mutations of the tau gene are present in atypical cases of SROS. The role of tau has been excluded in other(More)
In the framework of an extraterrestrial origin of biological homochirality, universal mechanisms are of particular interest. In this sense we consider the weak parity-violating neutrino-electron interaction through weak charged currents W (+/-) between the relic flux of cosmological neutrinos and the electrons of a chiral molecule. We use the known(More)
We examine the effect of cold dark matter on the discrimination between the two enantiomers of a chiral molecule. We estimate the energy difference between the two enantiomers due to the interaction between fermionic WIMPs (weak interacting massive particles) and molecular electrons on the basis that electrons have opposite helicities in opposite(More)
In order to explore parity violating effects in chiral molecules, of interest in some models of evolution towards homochirality, quantum stochastic resonance (QSR) is studied for the population difference between the two enantiomers of a chiral molecule (hence for the optical activity of the sample), under low viscous friction and in the deep quantum(More)
We study the tunnel dynamics of a chiral molecule between its left (L) and right (R) conformations, under the global effect of collisional decoherence together with the effect of a mean-field generated by the environment where an energetic difference, K, between homochiral and heterochiral interactions is assumed. We show that this decoherence leads(More)