Isabel Ezpeleta

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One approach to improve the bioavailability and efficiency of drugs consists of the association of a ligand (i.e. lectins), showing affinity for biological structures located on the mucosa surfaces, to nanoparticulate drug delivery systems. In this context, Ulex europaeus lectin-gliadin nanoparticle conjugates (UE-GNP) were prepared with the aim of(More)
Foetal/neonatal alloimmune thrombocytopenia is the most common cause of severe thrombocytopenia in the newborn. It is an acute disorder which implies that foetal platelets are destroyed during the pregnancy due to a maternal alloimmune IgG antibody. More than 80% of Caucasians are HPA-1a specific. Intracranial haemorrhage, which occurs in 30% of cases, is(More)
Between 1998-2002, 16,952 new cases of cancer were registered in Navarre. In men, the most frequently diagnosed cancers were in the following order: prostate, lung, colon and rectum, bladder and stomach, which accounted for 63.2%. In women, the sites were breast, colon and rectum, corpus uteri, stomach and ovary, which accounted for 57.6% of the cases. In(More)
The principal aim of this study was to determine the incidence of Myocardial Infarction in the population aged 25-74 in Navarra, lethality after 28 days, and the characteristics of the treatment applied in the hospitals during the years 1997-1998. A search was conducted for possible cases of heart attack in the hospital services responsible for attending to(More)
The influence of some selected factors on the properties of nano- and microparticles obtained from vicilin (storage protein from Pisum sativum L.) has been studied. These systems were prepared by coacervation followed by a cross-linking step with glutaraldehyde. Stabilized vicilin particles could be formed very rapidly after a short exposure to a low(More)
INTRODUCTION AND OBJECTIVES Smoking cessation reduces mortality in coronary patients. The aim of this study was to estimate association measures between the risk of occurrence of fatal or non-fatal reinfarction in patients who either continue to smoke or stop after a first infarction and are treated with secondary prevention measures. PATIENTS AND METHOD(More)
A electron microscopic and immunohistochemical study of a Melanotic medulloblastoma is reported. The cerebellar tumor was located in the vermis of a 6-year-old boy, dead 11 months after diagnosis. The tumor consisted of medulloblastoma-like areas with focal differentiation and pseudoepithelial structures pigmented with melanin. Electron microscopy showed(More)
A specific and sensitive reverse phase HPLC method (AO-1) for the quantitative determination of ten phenolic antioxidants and propyl paraben in fatty products (food, pharmaceuticals and cosmetics) has been developed. Extraction with acetonitrile from a hexane dilution of the products; acetic acid-water-acetonitrile-methanol solvent system and detection at(More)
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