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  • M. Patti, A. Butte, +14 authors L. Mandarino
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2003 (First Publication: 27 June 2003)
  • Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletalExpand
  • Lu Tian, Steven A. Greenberg, Sek Won Kong, Josiah Altschuler, Isaac S. Kohane, Peter J. Park
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 20 September 2005)
  • Accurate and rapid identification of perturbed pathways through the analysis of genome-wide expression profiles facilitates the generation of biological hypotheses. We propose a statistical frameworkExpand
  • Scott L. Carter, Aron Charles Eklund, Isaac S. Kohane, Lyndsay N. Harris, Zoltan Szallasi
  • Medicine, Biology
  • Nature Genetics
  • 2006 (First Publication: 1 September 2006)
  • We developed a computational method to characterize aneuploidy in tumor samples based on coordinated aberrations in expression of genes localized to each chromosomal region. We summarized the totalExpand
  • Judith N. Haslett, Despina Sanoudou, +5 authors Louis M. Kunkel
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2002 (First Publication: 1 November 2002)
  • The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene leading to the absence of the corresponding RNA transcript and protein. Absence of dystrophin leads toExpand
  • Atul J Butte, Pablo Tamayo, D. M. Slonim, Todd R. Golub, Isaac S. Kohane
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Publication: 24 October 2000)
  • In an effort to find gene regulatory networks and clusters of genes that affect cancer susceptibility to anticancer agents, we joined a database with baseline expression levels of 7,245 genesExpand