Isaac Mawenya

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BACKGROUND Holoprosencephaly is a rare spectrum of cephalic disorders resulting from a failure or incomplete division of the embryonic forebrain into distinct cerebral hemispheres. It is the most common brain malformation with an incidence of 1:250 during embryogenesis; however, owing to the associated high rates of spontaneous abortion the incidence is(More)
Introduction: Osteogenesis imperfecta (OI) is a spectrum of connective tissue disorders characterized by bones that break easily with little or no apparent cause. It is predominantly inherited in an autosomal dominant fashion and mutations affecting type I collagen, the main structural protein of the extracellular matrix of bone, skin, and other connective(More)
BACKGROUND Congenital complete heart block is a life-threatening condition which is highly associated with autoimmune and connective tissue disorders. Presence of maternal autoantibodies for associated conditions increases the risk of delivering a child with congenital complete heart block, however, less than a half of all women with such antibodies are(More)
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