Isaac M Macharia

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BACKGROUND The most important prognostic factor in head and neck cancer is the stage of the disease at presentation. Early cancer has an excellent prognosis following treatment. Unfortunately most patients present with late disease that requires radical treatment with considerable morbidity and mortality. Clinical experience at Kenyatta National Hospital(More)
BACKGROUND Depression is an important predictor of post therapy quality of life (QOL) in head and neck (H&N) cancer patients. In addition, depression rates may vary among cultures. OBJECTIVE As part of a larger cross cultural study on post therapy QOL differences in H&N cancer patients, the goal of this project was to translate a well-validated English(More)
OBJECTIVE To compare a topical quinolone antibiotic (ciprofloxacin) with a cheaper topical antiseptic (boric acid) for treating chronic suppurative otitis media in children. DESIGN Randomized controlled trial. SETTING AND PARTICIPANTS A total of 427 children with chronic suppurative otitis media enrolled from 141 schools following screening of 39 841(More)
OBJECTIVES To identify by type and sensitivity to drugs the bacteria found in ears of school-going children with chronic otitis media in Garissa district. METHODS STUDY DESIGN This was a descriptive prevalence study of CSOM bacterial flora in eligible ears conducted among a cohort of children attending public and private primary as well as Islamic(More)
BACKGROUND The distribution of congenital neck masses varies between countries and is important in diagnosis and treatment modalities. Data from Africa is scarce, and altogether absent from Kenya. OBJECTIVE To describe the pattern of congenital masses in a Kenyan paediatric population. SET UP: Kenyatta National Hospital, Nairobi Kenya. STUDY DESIGN(More)
HYPOTHESIS Cochlear implantation and deaf education are cost effective in Sub-Saharan Africa. BACKGROUND Cost effectiveness of pediatric cochlear implantation has been well established in developed countries but is unknown in low resource settings, where access to the technology has traditionally been limited. With incidence of severe-to-profound(More)
BACKGROUND Currently there is a dearth of data on the pattern of occurrence of head and neck cancers in Kenya. OBJECTIVE To provide a comprehensive analysis of the pattern of occurrence of head and neck cancers in a Kenyan population. DESIGN Retrospective hospital-based descriptive study. SETTING Kenyatta National Hospital, Nairobi. RESULT A total(More)
BACKGROUND The goal of this study was to obtain representative Kenyan data on the point prevalence of acute otitis media (AOM) and its sequelae (otitis media with effusion [OME] and chronic suppurative otitis media [CSOM]), a major cause of preventable hearing loss in children in developing countries. In Africa, there are limited studies on the prevalence(More)
OBJECTIVE To determine the bacteriology and antibiotic sensitivity of the bacterial isolates in chronic maxillary sinusitis patients seen at the Kenyatta National Hospital. DESIGN Cross-sectional study. SETTING Kenyatta National Hospital, ENT department. SUBJECTS AND METHODS Seventy-three patients had bilateral sntral washout done and the lavage(More)
BACKGROUND Adenotonsillectomy results in postoperative morbidity which otolaryngologists attempt to reduce by use of antibiotics. The regimes used as quite varied with some opting for a full oral course postoperatively while others prefer prophylactic doses. This randomised clinical trial done in Kenyatta National Hospital, Kenya had the aim of comparing(More)