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Microsatellites are tandem duplications with a simple motif of one to six bases as the repeat unit. Microsatellites provide an excellent opportunity for developing genetic markers of high utility because the number of repeats is highly polymorphic, and the assay to score microsatellite polymorphisms is quick and reliable because the procedure is based on(More)
We have developed an autosomal genetic linkage map of the chicken genome using a subpanel of 52 DNAs from a previously described reference backcross mapping population. The population derived from a cross of an inbred Red Jungle Fowl male and a highly inbred White Leghorn female. The backcross subpanel used was made up of offspring of a single F1 male with(More)
Commercially important traits of domestic animals have often been genetically linked to sex chromosomes, such as the Z chromosome of chickens. Using a backcross mapping population between two divergent, inbred lines and random-amplified polymorphic DNA (RAPD)-PCR markers, a genetic map of the chicken Z chromosome has been generated. Thirteen Z-linked RAPD(More)
Sex-linked slow-feathering gene, K, is genetically associated with the presence of an avian endogenous retrovirus ev21 in White Leghorns (WL). An EcoRI fragment corresponding to the endogenous virus ev21-cell junction fragment and a fragment homologous to the proviral unoccupied site (US) were cloned, respectively, from genomic DNA libraries of two WL(More)
The formation of secondary metastatic growths is characteristic of carcinoma as well as of sarcoma and presents the chief element of the malignancy of these tumors. A true metastatic growth is a secondary nodule formed in a distant organ or part of the body not contiguous to the primary tumor, and it should not be confused with even the most extensive local(More)
Endogenous virus (EV) locus ev6 encodes only virus envelope glycoprotein. The influence of ev6 on the immune response to contact infection with hatchmates infected with avian leukosis virus (ALV) was compared in replicate hatches. The ALV Subgroup E-resistant, rapid-feathering (RF) female chickens produced by slow-feathering (SF) and RF dams with and(More)
To investigate further the sex-linked, slow-feathering (SF) locus, a DNA hybridization probe that flanks the integration site of endogenous virus ev21 was used to probe Southern blots from a variety of commercial SF White Leghorn (WL), broiler, and endangered lines. After HaeIII digestion of DNA from SF WL, the 5' and 3' provirus-cell junction fragments(More)
PLATES 23-25. For all future investigation of the cancer problem, it is o,f the utmost importance to ascertain whether the disease is, in its early stages, a purely local condition and whether al.l the clinical' symptoms are subsequent to the dissemination of the tumor, or whether it is, even in its incipiency, a general parasitic or consti.t~ional disease.(More)
Cancer in the broadest meaning of the word, i. e., a malignant new growth formed through limitless cell proliferation~ may undoubtedly occur in any multicellular organism. In fact the investigations of the last decade, and mainly those of the Imperial Cancer Research Fund in London~ have shown that cancer may occur not only in every human race, but in(More)
Primers complementary to the chicken middle repetitive sequence element CR1 were used to generate and simultaneously map polymorphic polymerase chain reaction products (CR1-PCR) with various chicken DNAs as templates. Ten primers were prepared using the sequence of a single CR1 element as a guide. These 10 primers generated 23 polymorphic CR1-PCR products.(More)