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STUDY OBJECTIVES To test the hypotheses that the dynamic changes in brain oxygen partial pressure (PtO(2)) in response to obstructive apneas or to intermittent hypoxia differ from those in other organs and that the changes in brain PtO(2) in response to obstructive apneas is a source of oxidative stress. DESIGN Prospective controlled animal study. (More)
BACKGROUND Sleep fragmentation (SF) increases food intake and the risk of obesity, and recruits macrophages to visceral white adipose tissue (VWAT) promoting tissue inflammation and insulin resistance. Administration of resveratrol (Resv) has been associated with significant improvements in high-fat diet-induced obesity, inflammation and insulin resistance.(More)
STUDY OBJECTIVES To assess whether noninvasive application of nCPAP is a mechanical stimulus inducing early nasal inflammation. DESIGN Prospective controlled animal study. SETTING University laboratory. PATIENTS OR PARTICIPANTS 32 male Sprague-Dawley rats (250-300 g). INTERVENTIONS The rats were anesthetized and subjected to nCPAP=10 cm H2O and(More)
STUDY OBJECTIVES To determine whether the vibratory mechanical stimulus due to snoring induces upper-airway inflammation in an in-vivo rat model. DESIGN Prospective controlled animal study. SETTING University laboratory. PATIENTS OR PARTICIPANTS Sixteen male Sprague-Dawley rats (250-300 g). INTERVENTIONS The upper trachea of 8 rats was cannulated,(More)
STUDY OBJECTIVES To test a cell model of snoring-induced airway inflammation and to assess whether a vibration stimulus simulating the one experienced by airway tissues in snoring patients induces inflammation in airway epithelial cells. DESIGN Prospective controlled study in cell culture. SETTING University laboratory. PATIENTS OR PARTICIPANTS Human(More)
Obstructive sleep apnea (OSA) has recently been associated with an increased risk of cancer incidence and mortality in humans. Experimental data in mice have also shown that intermittent hypoxia similar to that observed in OSA patients enhances tumor growth. The aim of this study was to test the hypothesis that intermittent hypoxia mimicking OSA enhances(More)
Adult stem cells are undifferentiated cells that can be mobilized from the bone marrow or other organs, home into injured tissues, and differentiate into different cell phenotypes to serve in a repairing capacity. Furthermore, these cells can respond to inflammation and oxidative stress by exhibiting immunomodulatory properties. The protective and(More)
Sleep fragmentation (SF) is a highly prevalent condition and a hallmark of sleep apnea, a condition that has been associated with increased cancer incidence and mortality. In this study, we examined the hypothesis that sleep fragmentation promotes tumor growth and progression through proinflammatory TLR4 signaling. In the design, we compared mice that were(More)
Intermittent hypoxia (IH) has been extensively studied during the last decade, primarily as a surrogate model of sleep apnea. However, IH is a much more pervasive phenomenon in human disease, is viewed as a potential therapeutic approach, and has also been used in other disciplines, such as in competitive sports. In this context, adverse outcomes involving(More)