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STUDY OBJECTIVES To assess whether noninvasive application of nCPAP is a mechanical stimulus inducing early nasal inflammation. DESIGN Prospective controlled animal study. SETTING University laboratory. PATIENTS OR PARTICIPANTS 32 male Sprague-Dawley rats (250-300 g). INTERVENTIONS The rats were anesthetized and subjected to nCPAP=10 cm H2O and(More)
STUDY OBJECTIVES To test the hypotheses that the dynamic changes in brain oxygen partial pressure (PtO(2)) in response to obstructive apneas or to intermittent hypoxia differ from those in other organs and that the changes in brain PtO(2) in response to obstructive apneas is a source of oxidative stress. DESIGN Prospective controlled animal study. (More)
BACKGROUND Sleep fragmentation (SF) increases food intake and the risk of obesity, and recruits macrophages to visceral white adipose tissue (VWAT) promoting tissue inflammation and insulin resistance. Administration of resveratrol (Resv) has been associated with significant improvements in high-fat diet-induced obesity, inflammation and insulin resistance.(More)
BACKGROUND OSA increases atrial fibrillation (AF) risk and is associated with poor AF treatment outcomes. However, a causal association is not firmly established and the mechanisms involved are poorly understood. The aims of this work were to determine whether chronic obstructive sleep apnea (OSA) induces an atrial pro-arrhythmogenic substrate and to(More)
STUDY OBJECTIVES To test a cell model of snoring-induced airway inflammation and to assess whether a vibration stimulus simulating the one experienced by airway tissues in snoring patients induces inflammation in airway epithelial cells. DESIGN Prospective controlled study in cell culture. SETTING University laboratory. PATIENTS OR PARTICIPANTS Human(More)
STUDY OBJECTIVES To determine whether the vibratory mechanical stimulus due to snoring induces upper-airway inflammation in an in-vivo rat model. DESIGN Prospective controlled animal study. SETTING University laboratory. PATIENTS OR PARTICIPANTS Sixteen male Sprague-Dawley rats (250-300 g). INTERVENTIONS The upper trachea of 8 rats was cannulated,(More)
Obstructive sleep apnea (OSA) has recently been associated with an increased risk of cancer incidence and mortality in humans. Experimental data in mice have also shown that intermittent hypoxia similar to that observed in OSA patients enhances tumor growth. The aim of this study was to test the hypothesis that intermittent hypoxia mimicking OSA enhances(More)
Chronic intermittent hypoxia during sleep (IH), as occurs in sleep apnea, promotes systemic insulin resistance. Resveratrol (Resv) has been reported to ameliorate high-fat diet-induced obesity, inflammation, and insulin resistance. To examine the effect of Resv on IH-induced metabolic dysfunction, male mice were subjected to IH or room air conditions for 8(More)
Sleep fragmentation (SF) is a highly prevalent condition and a hallmark of sleep apnea, a condition that has been associated with increased cancer incidence and mortality. In this study, we examined the hypothesis that sleep fragmentation promotes tumor growth and progression through proinflammatory TLR4 signaling. In the design, we compared mice that were(More)