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Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies.

• Martin K Gelbard, Irwin S. Goldstein, +6 authors Culley Carson
• The Journal of urology
• 2013

PURPOSE IMPRESS (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies) I and II examined the clinical efficacy and safety of collagenase Clostridium histolyticum intralesional… (More)

The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study.

• Andre Araujo, Roberto Durante, Henry A. Feldman, Irwin S. Goldstein, John B Mckinlay
• Psychosomatic medicine
• 1998

OBJECTIVE Studies have shown that there is an association between depression and male erectile dysfunction (MED). However. these earlier studies suffer considerable methodological flaws including: a)… (More)

Validation of the decreased sexual desire screener (DSDS): a brief diagnostic instrument for generalized acquired female hypoactive sexual desire disorder (HSDD).

• Anita H. Clayton, Evan R. Goldfischer, Irwin S. Goldstein, Leonard R. Derogatis, Diane J Lewis-D'Agostino, Robert E. Pyke
• The journal of sexual medicine
• 2009

INTRODUCTION An accurate diagnosis of Hypoactive Sexual Desire Disorder (HSDD) currently relies on a time-consuming interview with an expert clinician. Limited access to such expertise means that… (More)

Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk?

• Carol A. Derby, Beth A. Mohr, Irwin S. Goldstein, Henry A. Feldman, Catherine B. Johannes, John B Mckinlay
• Urology
• 2000

OBJECTIVES To prospectively examine whether changes in smoking, heavy alcohol consumption, sedentary lifestyle, and obesity are associated with the risk of erectile dysfunction. METHODS Data were… (More)

Management of sexual dysfunction in patients with cardiovascular disease: recommendations of The Princeton Consensus Panel.

• Robert F Debusk, Yaakov Drory, +13 authors Randall M. Zusman
• The American journal of cardiology
• 2000

Sexual dysfunction is highly prevalent in both sexes and adversely affects patients' quality of life and well being. Given the frequent association between sexual dysfunction and cardiovascular… (More)

Mechanisms of venous leakage: a prospective clinicopathological correlation of corporeal function and structure.

• Ajay X Nehra, Irwin S. Goldstein, +7 authors Robert B. Moreland
• The Journal of urology
• 1996

PURPOSE We investigated the pathophysiology of structurally based corporeal veno-occlusive dysfunction. MATERIALS AND METHODS We prospectively evaluated 24 impotent patients (mean age plus or minus… (More)

International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation.

• Stanley E. Althof, Carmita H N Abdo, +23 authors Hui Meng Tan
• The journal of sexual medicine
• 2010

INTRODUCTION Over the past 20 years our knowledge of premature ejaculation (PE) has significantly advanced. Specifically, we have witnessed substantial progress in understanding the physiology of… (More)

Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection.

• Noel N Kim, Yoram Vardi, Harin Padma-nathan, Jennifer Daley, Irwin S. Goldstein, Iñigo Sáenz de Tejada
• The Journal of clinical investigation
• 1993

Relaxation of the trabecular smooth muscle of the corpus cavernosum (the erectile tissue) of the penis is mediated by nitric oxide released by the nerves and endothelium. We have investigated the… (More)

A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle.

• Noel N Kim, Kazem M. Azadzoi, Irwin S. Goldstein, Iñigo Sáenz de Tejada
• The Journal of clinical investigation
• 1991

This study was initiated to characterize nonadrenergic-noncholinergic (NANC) inhibitory neurotransmission in penile corpus cavernosum. Using organ baths, isometric tension measurements were made in… (More)

Female sexual dysfunction.

• Jennifer R. Berman, Irwin S. Goldstein
• The Urologic clinics of North America
• 2001

The ideal approach to female sexual dysfunction would be a collaborative effort between therapists and physicians and would include a complete medical and psychosocial evaluation, and inclusion of… (More)

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