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  • R Bruggera, Claudia Reichel, +4 authors Gerd Geisslinger
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 2001 (First Publication: 1 March 2001)
  • Our investigations of fatty acid metabolism and epimerization of the 2-arylpropionic acid derivative, R-ibuprofen, resulted in the successful purification of an acyl-CoA synthetase from rat liverContinue Reading
  • Jörn Lötsch, Inna Belfer, +7 authors Irmgard Tegeder
  • Medicine, Biology
  • Clinical chemistry
  • 2007 (First Publication: 19 April 2007)
  • BACKGROUND A haplotype in the GTP cyclohydrolase 1 (dopa-responsive dystonia) gene (GCH1) is associated with decreased persistent pain. The aim of the present study was to develop a screening methodContinue Reading
  • Alexandra Doehring, Charalambos Antoniades, Keith M Channon, Irmgard Tegeder, Jörn Lötsch
  • Biology, Medicine
  • Mutation research
  • 2008 (First Publication: 1 September 2008)
  • Guanosine triphosphate cyclohydrolase 1 (GCH1) is the first enzyme in the tetrahydrobiopterin (BH4) biosynthesis, an important co-factor for the formation of nitric oxide, biogenic amines andContinue Reading
  • Charalambos Antoniades, Cheerag Shirodaria, +12 authors Keith M Channon
  • Medicine
  • Journal of the American College of Cardiology
  • 2008 (First Publication: 1 July 2008)
  • OBJECTIVES This study sought to determine the effects of endogenous tetrahydrobiopterin (BH4) bioavailability on endothelial nitric oxide synthase (eNOS) coupling, nitric oxide (NO) bioavailability,Continue Reading