Irmeli Lautenschlager

Learn More
Chromosomally integrated human herpesvirus 6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other(More)
BACKGROUND The occurrence and clinical course of late primary CMV infections developing after valganciclovir prophylaxis in high-risk renal transplant recipients are poorly described. METHODS Helsinki University Hospital district kidney allograft recipients between January 2004 and March 2007 (N = 175) were prospectively investigated. Patients with D+/R-(More)
BACKGROUND Major risk factors for accelerated allograft arteriosclerosis include humoral and cellular immune response, hyperlipidemia, and viral infections. We demonstrated earlier that rat cytomegalovirus (RCMV) infection doubles smooth muscle cell proliferation and intimal thickening of rat aortic allografts. In this study, the effects of(More)
BACKGROUND Quantification of cytomegalovirus (CMV) load is central to the management of CMV infections in immunocompromised patients, but quantitative results currently differ significantly across methods and laboratories. METHODS The COBAS AmpliPrep/COBAS TaqMan CMV Test (CAP/CTM CMV test), developed using the first World Health Organization CMV standard(More)
Nucleic acid sequence-based amplification (NASBA) was used for detection of the human cytomegalovirus (CMV) immediate early-1 (IE) and the late pp67 mRNA in 353 blood samples collected from 34 liver transplant patients. The diagnostic value of these assays was compared to that of the pp65 antigenemia assay. Overall, 95 and 42% of the antigenemia-positive(More)
1. Classic polyomaviruses: basic perspectives Kamel Khalili 2. Discovery and characterization of novel polyomaviruses in humans Dave Wang 3. Discovery of polyomaviruses in humans and nonhuman primates Bernhard Ehlers 4. Crystal structures of the major capsid protein VP1 from human polyomavirus 9 and African green monkey polyomavirus provide a foundation for(More)
List of original publications 7 Abbreviations 8 Summary 9 Review of the literature 10 1. Human cytomegalovirus 10 1.1. Virus structure and genome organization 10 1.2. Virus replication 10 1.3. Epidemiology and transmission 11 1.4. Pathogenesis 12 2. Human cytomegalovirus infections in organ transplant patients 14 2.1. Clinical manifestations 14 2.2.(More)
  • 1