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To estimate the genetic risk associated with pesticide exposure in a defined population, the frequency of micronuclei (MN) in peripheral blood lymphocytes from a group of 22 pesticide sprayers from Concepción, Chile, occupationally exposed to pesticide mixtures was evaluated. After scoring 1,000 binucleated cells for each donor, no significant increases(More)
Chordomas are tumors with a bad prognosis, because of their location, local aggressiveness and high rate of local relapse. Despite of be benign tumors, they have certain capacity of metastasize and a clinical evolution that results interesting. When we analyzed our series with 35 chordomas studied and treated between 1975 and 2002, we found three patients(More)
PURPOSE To compare, in a randomized trial, 5-fluorouracil (FU) plus leucovorin (LV) (FU+LV) vs. oral uracil and tegafur (UFT) plus LV (UFT+LV) given concomitantly with preoperative irradiation in patients with cT3-4 or N+ rectal cancer. METHODS AND MATERIALS A total of 155 patients were entered onto the trial. Patients received pelvic radiotherapy(More)
Several thalamic nuclei are associated with the processing of pain information and are influenced by cortical actions. This paper demonstrates a cortical influence upon the medial thalamic nuclei unit activity evoked by thermal noxious stimulation in rats. We studied the effects of cortical spreading depression (CSD) upon the responses of the centralis(More)
PURPOSE To examine the potential radiosensitising properties of trabectedin (ET-743, Yondelis). METHODS AND MATERIALS In vitro chemosensitivity was assessed in four tumour cell lines (DU145, HeLa, HT29, HOP62) by the crystal violet method. IC10s and IC50s were established for 1-h, 24-h and 7-day (continuous) exposure times. Radiosensitisation was(More)
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