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Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking.

• Irma Onoprishvili, Matthew L. Andria, H. Kenneth Kramer, Natasa Ancevska-Taneva, Jacob M. Hiller, Eric J. Simon
• Molecular pharmacology
• 2003

The carboxyl tail of the human mu opioid receptor was shown to bind the carboxyl terminal region of human filamin A, a protein known to couple membrane proteins to actin. Results from yeast… (More)

Delta Opioid activation of the Mitogen-activated protein kinase cascade does not require transphosphorylation of Receptor Tyrosine Kinases

• H. Kenneth Kramer, Irma Onoprishvili, +4 authors Eric J. Simon
• BMC pharmacology
• 2002

BACKGROUND In this study, we investigated the mechanism(s) by which delta opioids induce their potent activation of extracellular signal-regulated protein kinases (ERKs) in different cell lines… (More)

The bovine mu-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cells.

• Irma Onoprishvili, Matthew L. Andria, Ferdinand S. Vilim, Jacob M. Hiller, Eric J. Simon
• Brain research. Molecular brain research
• 1999

The cDNA coding for the bovine mu-opioid receptor has been cloned and sequenced. Conserved sequences from murine delta-receptor cDNA were used as primers in polymerase chain reaction (PCR) to amplify… (More)

Filamin A Mutant Lacking Actin-Binding Domain Restores Mu Opioid Receptor Regulation in Melanoma Cells

• Irma Onoprishvili, Solav Ali, Matthew L. Andria, Adam Shpigel, Eric J. Simon
• Neurochemical Research
• 2008

We have previously reported that the protein filamin A (FLA) binds to the carboxyl tail of the mu opioid receptor (MOPr). Using human melanoma cells, which do not express filamin A, we showed that… (More)

Chronic morphine treatment up-regulates mu opioid receptor binding in cells lacking filamin A

• Irma Onoprishvili, Eric J. Simon
• Brain Research
• 2007

We investigated the effects of morphine and other agonists on the human mu opioid receptor (MOP) expressed in M2 melanoma cells, lacking the actin cytoskeleton protein filamin A and in A7, a subclone… (More)

A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor

• Natasa Ancevska-Taneva, Irma Onoprishvili, Matthew L. Andria, Jacob M. Hiller, Eric J. Simon
• Brain Research
• 2006

A yeast two-hybrid screen, using the carboxyl tail of the human mu opioid receptor as bait and a human brain cDNA library as target, indicated that the carboxyl terminal portion of hlj1, a member of… (More)

The Interaction Between the Mu Opioid Receptor and Filamin A

• Eric J. Simon, Irma Onoprishvili
• Neurochemical Research
• 2010

Our laboratory embarked on research to discover proteins the interaction of which with the mu opioid receptor (MOPr) is required for its function and regulation. We performed yeast two-hybrid… (More)

Inactivation of the Purified Bovine μ Opioid Receptor by Sulfhydryl Reagents

• Theresa Lee Gioannini, Irma Onoprishvili, Jacob M. Hiller, Eric J. Simon
• Neurochemical Research
• 1999

We have investigated the role of cysteine residues in a highly purified μ opioid receptor protein (μORP) by examining the effect of -SH reagents on the binding of opioid ligands. Treatment of μORP,… (More)

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