Irma Nydegger

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Inorganic phosphate (Pi) is an important polyanion needed for ATP synthesis and bone formation. As it is found at millimolar levels in plasma, it is usually incorporated as a constituent of artificial CSF formulations for maintaining brain slices. In this paper, we show that Pi limits the extracellular zinc concentration by inducing metal precipitation. We(More)
The synaptic vesicles of some glutamatergic terminals contain a high concentration of zinc that serves functions that remain obscure. In this publication we have used the membrane permeant zinc fluophore, ZnAF-2 to determine if zinc is released during the course of synaptic transmission. Stimulation of the slices with either high potassium or electrically,(More)
Ionic zinc is found at a high concentration in some glutamatergic vesicles of the mammalian brain. Ionic zinc is also found chelated to macromolecules in the extracellular space, constituting what has been called the "zinc veneer". In this communication we show that the zinc ionophore, pyrithione, can be used to demonstrate the presence of the veneer.(More)
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