Iris M De Cuyper
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Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice.
BACKGROUND/AIM Mutations in genes encoding the ATP-binding cassette (ABC)-transporters ABCG5 and ABCG8 underlie sitosterolemia, which is characterized by elevated plasma levels of phytosterols due to… Expand
A novel flow cytometry-based platelet aggregation assay.
The main function of platelets is to maintain normal hemostasis. Inefficient platelet production and/or defective platelet function results in bleeding disorders resulting from a wide range of… Expand
Abundance of Early Functional HIV-Specific CD8+ T Cells Does Not Predict AIDS-Free Survival Time
Background T-cell immunity is thought to play an important role in controlling HIV infection, and is a main target for HIV vaccine development. HIV-specific central memory CD8+ and CD4+ T cells… Expand
Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency.
- T. Kuijpers, A. T. Tool, +15 authors T. K. van den Berg
- The Journal of allergy and clinical immunology
- 1 July 2017
Citation for published version: Kuijpers, TW, Tool, A, van der Bijl, I, Boer, MD, van Houdt, M, de Cuyper, I, Roos, D, van Alphen, FPJ, van Leeuwen, K, Cambridge, EL, Arends, M, Dougan, G, Clare, S,… Expand
Analysis of the effect of highly active antiretroviral therapy during acute HIV-1 infection on HIV-specific CD4 T cell functions
Background:It has been reported that antiretroviral therapy (HAART) during acute HIV-1 infection may rescue HIV-1-specific CD4 T cell responses. Objective:To determine the duration of this preserved… Expand
Prognostic value of HIV-1 Gag-specific CD4+ T-cell responses for progression to AIDS analyzed in a prospective cohort study.
- C. Jansen, Iris M De Cuyper, B. Hooibrink, A. K. van der Bij, D. van Baarle, F. Miedema
- 15 February 2006
The causal relationship between HIV-specific CD4+ T-cell responses and viral control and the effect of these responses on the natural history of HIV infection is unclear. In a detailed longitudinal… Expand
Reconstitution of EBV Latent but Not Lytic Antigen-Specific CD4+ and CD8+ T Cells after HIV Treatment with Highly Active Antiretroviral Therapy 1
- E. Piriou, C. Jansen, +6 authors D. van Baarle
- Biology, Medicine
- The Journal of Immunology
- 1 August 2005
The incidence of (EBV-related) malignancies in HIV-infected subjects has declined since the introduction of highly active antiretroviral therapy (HAART). To investigate the effect of HAART on EBV… Expand
Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO-CD27- phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease.
To identify factors related to progression to CMV end-organ disease, cytokine production, proliferative capacity and phenotype of CMV-specific CD4(+) T-cells were analysed longitudinally. Numbers of… Expand
Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment
During hematopoiesis, transcriptional programs are essential for the commitment and differentiation of progenitors into the different blood lineages. GATA1 is a transcription factor expressed in… Expand
Influence of pH on stored human platelets
- D. Dekkers, Iris M De Cuyper, P. F. van der Meer, A. Verhoeven, D. de Korte
- 1 October 2007
BACKGROUND: During storage at room temperature, platelets (PLTs) undergo several changes, a process known as PLT storage lesion. The pH is one of the variables changing and has been suggested to be a… Expand