Learn More
A database search of the Paramecium genome reveals 34 genes related to Ca(2+)-release channels of the inositol-1,4,5-trisphosphate (IP(3)) or ryanodine receptor type (IP(3)R, RyR). Phylogenetic analyses show that these Ca(2+) release channels (CRCs) can be subdivided into six groups (Paramecium tetraurelia CRC-I to CRC-VI), each one with features in part(More)
In the ciliate Paramecium, a variety of well characterized processes are regulated by Ca2+, e.g. exocytosis, endocytosis and ciliary beat. Therefore, among protozoa, Paramecium is considered a model organism for Ca2+ signaling, although the molecular identity of the channels responsible for the Ca2+ signals remains largely unknown. We have cloned - for the(More)
The pathogenesis of myasthenia gravis is autoimmune, the real etiology, however, remains unknown. Virus has been suggested as an etiological agent of the disease. In this study we present 5 myasthenic patients, whose symptoms began a few weeks after a proven viral infection. The possibility of viral infection as etiology of myasthenia gravis is raised, and(More)
Several approaches have been used to study the interactions of the subunits of protein kinase CK2. The inactive mutant of CK2α that has Asp 156 mutated to Ala (CK2αA156) is able to bind the CK2β subunit and to compete effectively in this binding with wild-type subunits α and α′. The interaction between CK2αA156 and CK2β was also demonstrated by transfection(More)
Protein kinase CK2 is ubiquitous in eukaryotes and is known to phosphorylate many protein substrates. The enzyme is normally a heterotetramer composed of catalytic (α and α′) and regulatory (β) subunits. The physiological regulation of the enzyme is still unknown but one of the factors that may play an important role in this regulation is the ratio of the(More)
  • 1