Previous studies have shown that genistein increased cystic fibrosis transmembrane conductance regulator (CFTR) channel activity in the presence of saturating concentrations of forskolin and calyculin A in intact cells. Possible molecular mechanisms for genistein's action include inhibition of tyrosine kinases, inhibition of serine/threonine protein… (More)
By concentrating carbon-14 through thermal diffusion, it is possible to extend the range of carbon-14 dating to 75,000 years ago. Samples with very low contamination levels have been encountered, and a reliable chronology appears possible. A Pacific Northwest climatic curve has been derived from palynological studies. The Pacific Northwest curve and the… (More)
Both potassium/argon and carbon-14 ages of lava flows and tephra layers interstratified with glacial deposits on Mauna Kea, Hawaii, indicate that four episodes of ice cap glaciation culminated about 20,000, 55,000, 135,000, and 250,000 years ago. These episodes are correlated with marine isotope stages 2, 4, 6, and 8, marking times of high global ice volume.