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Evolution of GPCR: Change and continuity
Structural and Functional Evolution of the Trace Amine-Associated Receptors TAAR3, TAAR4 and TAAR5 in Primates
- Claudia Stäubert, Iris Böselt, J. Bohnekamp, Holger Römpler, W. Enard, T. Schöneberg
- BiologyPloS one
- 15 June 2010
It is suggested that the previously identified volatile amine TAAR3–5 agonists reflect the high agonist promiscuity of TAAR, and that the ligands driving purifying selection of these TAAR in mouse and other mammals still await discovery.
Involvement of the V2 Vasopressin Receptor in Adaptation to Limited Water Supply
Comparison of over 80 mammalian V2 vasopressin receptor (V2R) orthologs revealed high structural and functional conservation of this key component involved in renal water reabsorption, indicating an essential role of V2R activity for survival even of those species with unlimited access to water.
Involvement of the chemokine-like receptor GPR33 in innate immunity.
Functional characterization of novel loss-of-function mutations in the vasopressin type 2 receptor gene causing nephrogenic diabetes insipidus.
- Iris Böselt, D. Tramma, A. Schulz
- Biology, MedicineNephrology, dialysis, transplantation : official…
- 1 April 2012
In-depth in vitro characterization of novel AVPR2 mutants by a combination of functional and immunological techniques provided further insight into molecular mechanisms causing receptor dysfunction and proof that these mutations are responsible for causing NDI in the affected subjects.