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INTRODUCTION During the last decade, minimally invasive surgery had an astonishing development, progressing from minor hepatic interventions to major hepatectomies, thus creating a rich background for robotic-assisted hepatic surgery. Left lateral hepatic segmentectomy (left lobectomy, II-III bi-segmentectomy) is the first anatomic hepatic resection on the(More)
BACKGROUND/AIMS The precise details of pancreatic ductal adenocarcinoma (PDAC) pathogenesis are still insufficiently known, requiring the use of high-throughput methods. However, PDAC is especially difficult to study using microarrays due to its strong desmoplastic reaction, which involves a hyperproliferating stroma that effectively "masks" the(More)
BACKGROUND Hepatitis C virus (HCV) recurrence after liver transplantation (LT) is almost universal, but the natural history of recurrent HCV in the allograft is highly variable. Our study had two aims: 1) to assess the impact of different pre- and postLT factors on graft and patient survival in HCV transplant recipients and 2) to create a model which may(More)
Pancreatic head cancer is a disease with a dismal prognosis, even after curative intent surgery, Resection represents the only hope for long-term survival. The negative resection margins (R0 resection) represent a strong independent prognostic factor. Up to 80% of so-called curative resections are, in fact, non-curative (with microscopically positive(More)
BACKGROUND Robotic surgery was developed in response to the limitations and drawbacks of laparoscopic surgery. Since 1997 when the first robotic procedure was performed various papers pointed the advantages of robotic-assisted laparoscopic surgery, this technique is now a reality and it will probably become the surgery of the future. The aim of this paper(More)
BACKGROUND Robotic approach for rectal cancer competes with laparoscopy in centers dedicated to minimally invasive surgery (MIS) due to the technologic advantage. This is a report of our experience with MIS for rectal cancer. METHODS A series of 84 consecutive patients with laparoscopic resection (between 1995-2010) and 38 consecutive patients with(More)
BACKGROUND Regret-based decision curve analysis (DCA) is a framework that assesses the medical decision process according to physician attitudes (expected regret) relative to disease-based factors. We sought to apply this methodology to decisions around the operative management of intrahepatic cholangiocarcinoma (ICC). METHODS Utilizing a multicentric(More)
Hepatic stem cells can be identified by the expression of putative markers such as CD117 (c-kit), CD90 (Thy-1), CD34, and HLA-DR. We have identified populations expressing these markers in both fetal and tumoral human liver by flow cytometry, using monoclonal antibodies against CD90, CD117, CD34, and HLA-DR. In tumoral liver CD117+/CD90+ cells were found in(More)
OBJECTIVE The aim of this study was to analyze the 10-year results of thoracoscopic unilateral extended thymectomy (TUET) performed in nontumoral myasthenia gravis according to the Myasthenia Gravis Foundation of America recommendations. BACKGROUND DATA Thoracoscopic unilateral extended thymectomy has the benefits of a minimally invasive approach.(More)
BACKGROUND/AIMS Neuroendocrine tumours occur very rarely in the ampulla of Vater and their clinical behaviour is unknown. The aim of this study is to assess the clinico-pathological features, surgical approach and prognosis of these patients. METHODS Six patients with neuroendocrine tumours of the ampulla of Vater treated with curative intent surgery at a(More)