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Agouti-related peptide is expressed in the hypothalamic neurons in humans and animals. Immunohistochemical studies in Wistar rats shows significant changes in the optical density of agouti-related peptide in the neurons of the arcuate hypothalamic nucleus, as well as in their processes in the hypothalamus and nucleus accumbens after 6 h of sleep deprivation(More)
The dynamics of changes in electrophysiological measures of the sleep-waking cycle were analyzed in Wistar rats after 6 h of sleep deprivation by gentle waking and subsequent 9-h post-deprivation sleep. A delayed sleep "overshoot" reaction was observed 2.5-3 h after sleep deprivation, as a moderate increase in the proportions of slow-wave and fast-wave(More)
Heat shock protein 70 kDa (Hsp70) possesses a remarkable neuroprotective activity and the results of recent studies demonstrated its efficacy in the attenuation of epileptic seizures. The aim of this study was to explore the effects of a pure Hsp70/Hsc70 preparation delivered to the brain regions involved in generalized seizures induced in rats by(More)
BACKGROUND Most obese individuals have elevated concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), markers of inflammation closely associated with diabetes, hypertension, and stroke. HYPOTHESIS Obesity is a low-grade inflammatory disease, and Roux-en-Y gastric bypass (RYGB) reduces biochemical markers of inflammation and(More)
In Wistar rats, after 6 h of sleep deprivation and subsequent 2 h postdeprivation sleep, we found significant changes in optical density of CART peptide in neurons of nucleus accumbens and hypothalamic nucleus arcuatus as well as in processes coming into substantia nigra from nucleus accumbens. The obtained data revealed unidirectional changes of optical(More)
Decreases in the activity of the ubiquitin-proteasome system lead to the accumulation of toxic forms of proteins and cell degeneration, including dopaminergic neurons in the substantia nigra; these neurons are characterized by proteasomes with low proteolytic activity, such that they are more susceptible, especially during exposure to neurotoxins and the(More)
Decreases in the activity of the ubiquitin-proteasome system (UPS), which uses up to 90% of cell protein, are regarded as a key mechanism in the development of age-related conformational diseases (Parkinson’s disease (PD), Alzheimer’s disease, and others). Studies in a model of the preclinical stage of PD in Wistar rats showed that the specific UPS(More)
Results obtained from comparative immunohistochemical studies of dopamine-containing neurons and fibers in the telencephalic and diencephalic parts of the brain in cold-blooded animals (frogs) and warmblooded (14- and 30-day-old rat pups and adult) vertebrates are presented. The dynamics of quantitative changes in tyrosine hydroxylase and D1- and(More)
BACKGROUND Effects of Roux-en-Y gastric bypass (RYGB) on hypothalamic food intake regulation have not been investigated. The hypothalamic arcuate nucleus (ARC) and the magnocellular (m) and parvocellular (p) parts of the paraventricular nucleus (PVN) regulate hunger and satiety, and are under control of the orexigenic neuropeptide Y (NPY), and the(More)
BACKGROUND Dietary fish oil (rich in omega-3 fatty acids: eicosapentaenoic acid and docosahexaenoic acid) suppresses synthesis and activity of proinflammatory cytokines that induce anorexia. We hypothesized that dietary fish oil reverses the feeding pattern of tumor anorexia, increasing food intake and retarding tumor growth. STUDY DESIGN Thirty-two(More)