Irina Pugach

Publications19
h-index11
Citations1,511
Highly Influential Citations109
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Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania.
A genomic history of Aboriginal Australia
TLDR
A population expansion in northeast Australia during the Holocene epoch associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama–Nyungan languages is inferred.
Genetic Variation and Recent Positive Selection in Worldwide Human Populations: Evidence from Nearly 1 Million SNPs
TLDR
Two genes involved in the thyroid hormone pathway that show signals of selection in African Pygmies that may be related to their short stature are identified.
Genome-wide data substantiate Holocene gene flow from India to Australia
TLDR
An ancient association is found between Australia, New Guinea, and the Mamanwa (a Negrito group from the Philippines), with divergence times for these groups estimated at 36,000 y ago, supporting the view that these populations represent the descendants of an early “southern route” migration out of Africa, whereas other populations in the region arrived later by a separate dispersal.
Positive Selection in East Asians for an EDAR Allele that Enhances NF-κB Activation
TLDR
Evidence is presented that a derived nonsynonymous substitution (370A) in EDAR, a gene involved in ectodermal development, was driven to high frequency in East Asia by positive selection prior to 10,000 years ago.
Dating the age of admixture via wavelet transform analysis of genome-wide data
TLDR
A PCA-based genome scan approach to analyze genome-wide admixture structure is described, and wavelet transform analysis is introduced as a method for estimating the time of admixture.
Genetic dating indicates that the Asian–Papuan admixture through Eastern Indonesia corresponds to the Austronesian expansion
TLDR
The results indicate that the Austronesian expansion had a strong genetic as well as linguistic impact on Island Southeast Asia, and they significantly advance the understanding of the biological origins of human populations in the Asia–Pacific region.
The Complex Admixture History and Recent Southern Origins of Siberian Populations
TLDR
Geogenetic maps are analyzed and other approaches are used to distinguish the effects of shared ancestry from prehistoric migrations and contact, and a new method based on the covariance of ancestry components is developed, to investigate the potentially complex admixture history of Siberian populations.
The Gateway from Near into Remote Oceania: New Insights from Genome-Wide Data
TLDR
This study points to the importance of fine‐scale sampling to understand the complexities of human population history and uses simulations to show that discrepancies between different methods for dating admixture likely reflect different sensitivities of the methods to multiple admixture events from the same (or similar) sources.
The Current Genomic Landscape of Western South America: Andes, Amazonia, and Pacific Coast
TLDR
The genetic structure of 176 individuals from these three domains, genotyped with the Affymetrix Human Origins array, is explored, infer multiple sources of ancestry within the Native American ancestry component and illustrates the potential of SNP chip arrays for informative regional-scale analysis.
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