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This randomized, open-label, active-controlled, dose-finding phase IIb study evaluated the efficacy and safety of trabedersen (AP 12009) administered intratumorally by convection-enhanced delivery compared with standard chemotherapy in patients with recurrent/refractory high-grade glioma. One hundred and forty-five patients with central reference(More)
Efficacy and tolerability of once-daily adjunctive lamotrigine extended-release (XR) for primary generalized tonic-clonic (PGTC) seizures in epilepsy were evaluated. Patients (n = 153) ≥ 13 years old diagnosed with epilepsy with PGTC seizures were randomized to once-daily adjunctive lamotrigine XR or placebo in a double-blind, parallel-group trial(More)
The authors studied 600 cases of supratentorial tumors of the brain. The clinical picture in 306 of them (51%) was marked by epileptic seizures. They analysed the frequency of various types of epileptic seizures according to the localization and histological structure of the tumors. On basis of the results of complex clinico-electrophysiological examination(More)
A state of the autonomic nervous system is known to play an important role in complex treatment of any somatic pathology. The drugs with complex anxiolytic, autonomic stabilizing and nootropic effects are used in treatment of autonomic disorders. These drugs stabilize as the general mental condition, including emotional state, as well as the autonomic(More)
OBJECTIVE To study the characteristics of asthenic syndrome in elderly people after acute respiratory viral infection. MATERIAL AND METHODS We examined 87 patients with chronic cerebral ischemia and other comorbid disorders, aged from 63 to 78 years. Patients were randomized to two groups. Patients of the main group received mexidol (1 tablet (125 mg) 3(More)
Course and outcome of 200 pregnancies, deliveries and post-partum periods of 127 women with the onset of epilepsy before or during pregnancy were compared to clinical form of the disease, frequency of seizures and antiepileptic therapy. In addition, 104 children born to 97 mothers with epilepsy, 85 children--from the moment of birth to 1 year old and others(More)
Multiple sclerosis (MS) today is a wide-spread disease of young adults of 22-25 years of age, which influences their everyday life, affecting movement, behavior and family life. After 2-5 years of untreated MS the patients become complete invalids. The organization of the process of rehabilitation for these patients includes the activity to restore MS(More)
The paper presents experience in embolizing arterial aneurysm, which of great value for interventional radiology. Endovascular embolization is a low-traumatic intervention, which reduces the time of rehabilitation in a patient and makes him active much earlier. The paper uses a sufficient body of data to provide evidence for the efficiency and safety of(More)
We followed up 102 patients with a monofocal clinically isolated syndrome (CIS) during 8 years. Factors determining its transition to definite multiple sclerosis were singled out according to the data of anamnesis and MRI scans. Age of patients at the onset of CIS and the volume of demyelination measured by the first MRI were the most significant predictors(More)