Irina P Levshina

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403 Chronic stress results in functional disturbances in the CNS, possibly due to death of neuronal cells or their substantial structural changes. Hippocampal atrophy was found in patients with disorders related to repeated depression or posttraumatic stress syndrome [12]. Under experimental conditions, chronic three week immobilization stress or(More)
Chronic stress causes changes in neuroplasticity that are accompanied by structural changes in the neocortex and hippocampus. In this study, parameters of oxidative stress and apoptosis were investigated in different areas of rat brains subjected to chronic stress (on the model of experimental neurosis). It was found that this chronic stress induced a(More)
1. The stage of long-term adaptation of rats to chronic emotional-pain stress is characterized by an increase in the Superoxide dismutase activity of the brain and the superoxidescavenging activity of the blood serum, the accumulation of fluorescent products of freeradical oxidation, and a decrease in the content of phospholipids and cholesterol in lipid(More)
Depression is the most common form of mental disability in the world. Depressive episodes may be precipitated by severe acute stressful events or by mild chronic stressors. Studies on the mechanisms of depression require both appropriate experimental models (most of them based on the exposure of animals to chronic stressors), and appropriate tests for(More)
Hippocampus is believed to be selectively vulnerable to stress. We hypothesized that this phenomenon may be mediated by relatively high vulnerability to neuroinflammation related to impairments of local glucocorticoid metabolism and signaling. We have evaluated inflammatory responses induced by acute or chronic combined stress in the cerebral cortex and(More)
Intellectual abilities of mathematicians led them to the creation of some number systems, among which the set of real numbers occupies a special place. A visual representation which would distinguish between the rational number system and the real number system was not found. Nevertheless, the set theory of real numbers was understood and accepted by(More)
Rats were exposed to white noise for 1, 2 and 3 weeks. Electron microscopy was used to examine brain sections. The number of synaptic junctions was calculated in the auditory and motor areas of the brain cortex. It has been shown that there was a significantly incremental increase in the number of synaptic junctions in all the layers of the auditory and(More)
Reactions of the glia and blood vessels in the sensomotor cortex of adult rats to intraperitoneal injection of angiotensin II were studied electron-microscopically. Repeated injections of the hormone led to edema of increasing severity of the astrocytes, constriction of the lumen of the capillaries, and changes in the structure of their endothelium. It is(More)
Behavior of 19 Chinchilla rabbits was tested in the open field. By the results of the first trial, animals were divided into three groups by the type of the exploratory locomotor activity (passive--37%; active--21; and medium--42%). During the repeated open field trials, the passive rabbits increased their activity and the active ones decreased it.(More)
Changes of vegetative reactions and cytochrome oxidase (CChO) activity in various brain structures were studied in rats during neurotization. One week neurotization led to an increase of arterial blood pressure, respiration rate, cardiac stroke volume and heart rate. In three weeks of neurotization there was a decrease of stroke volume accompanied by an(More)